Nesfatin-1 and ghrelin levels in serum and saliva of epileptic patients: Hormonal changes can have a major effect on seizure disorders

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dc.contributor.authorAydin S.
dc.contributor.authorDag E.
dc.contributor.authorOzkan Y.
dc.contributor.authorErman F.
dc.contributor.authorDagli A.F.
dc.contributor.authorKilic N.
dc.contributor.authorSahin I.
dc.contributor.authorKaratas F.
dc.contributor.authorYoldas T.
dc.contributor.authorBarim A.O.
dc.contributor.authorKendir Y.
dc.date.accessioned2024-07-22T08:21:52Z
dc.date.available2024-07-22T08:21:52Z
dc.date.issued2009
dc.description.abstractNesfatin-1 and ghrelin are the two recently discovered peptide hormones involved in the control of appetite. Besides its main appetite-control function, ghrelin also has anticonvulsant effects, while nesfatin-1 causes depolarization in the paraventricular nucleus (PVN). The aims of this study, therefore, were to investigate: (i) whether there are differences in the concentrations of nesfatin-1 and ghrelin in saliva and serum samples between eplilepsy patients and normal controls and (ii) whether salivary glands produce nesfatin-1. The study included a total of 73 subjects: 8 patients who were newly diagnosed with primary generalized seizures and had recently started antiepileptic drug therapy; 21 who had primary generalized seizures and were continuing with established antiepileptic drug therapy; 24 who had partial seizures (simple: n = 12 or complex: n = 12) and were continuing with established antiepileptic drug therapy; and 20 controls. Salivary gland tissue samples were analyzed for nesfatin-1 expression by immunochemistry and ELISA. Saliva and serum ghrelin levels were measured by ELISA and RIA, and nesfatin-1 levels by ELISA. Nesfatin-1 immunoreactivity was detected in the striated and interlobular parts of the salivary glands and the ducts. The nesfatin-1 level in the brain was around 12 times higher than in the salivary gland. Before antiepileptic treatment, both saliva and serum nesfatin-1 levels were around 160-fold higher in patients who are newly diagnosed with primary generalized epilepsy (PGE) than in controls; these levels decreased with treatment but remained about 10 times higher than the control values. Saliva and serum nesfatin-1 levels from patients with PGE and partial epilepsies who were continuing antiepileptic drugs were also 10-fold higher than control values. Serum and saliva ghrelin levels were significantly (twofold) lower in epileptic patients before treatment than in controls; they recovered somewhat with treatment but remained below the control values. These results suggest that the low ghrelin and especially the dramatically elevated nesfatin-1 levels might contribute to the pathophyisology of epilepsy. Therefore, serum and saliva ghrelin and especially the remarkably increased nesfatin-1 might be candidate biomarkers for the diagnosis of epilepsy and for monitoring the response to anti-epileptic treatment. © Springer Science+Business Media, LLC. 2009.
dc.identifier.DOI-ID10.1007/s11010-009-0073-x
dc.identifier.issn15734919
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18807
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAnticonvulsants
dc.subjectBiological Markers
dc.subjectCase-Control Studies
dc.subjectEpilepsies, Partial
dc.subjectEpilepsy
dc.subjectFemale
dc.subjectGhrelin
dc.subjectHumans
dc.subjectMale
dc.subjectNerve Tissue Proteins
dc.subjectPeptide Hormones
dc.subjectSaliva
dc.subjectSalivary Glands
dc.subjectYoung Adult
dc.subjectcarbamazepine
dc.subjectghrelin
dc.subjectnesfatin 1
dc.subjectpeptide hormone
dc.subjectphenytoin
dc.subjectunclassified drug
dc.subjectvalproic acid
dc.subjectadult
dc.subjectarticle
dc.subjectbrain level
dc.subjectcontrolled study
dc.subjectenzyme linked immunosorbent assay
dc.subjectepilepsy
dc.subjectfemale
dc.subjectfocal epilepsy
dc.subjectgrand mal seizure
dc.subjecthormone action
dc.subjecthormone blood level
dc.subjecthormone synthesis
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectprotein expression
dc.subjectprotein localization
dc.subjectradioimmunoassay
dc.subjectsaliva level
dc.subjectsalivary gland
dc.subjectsalivary gland duct
dc.subjecttissue distribution
dc.subjecttreatment response
dc.titleNesfatin-1 and ghrelin levels in serum and saliva of epileptic patients: Hormonal changes can have a major effect on seizure disorders
dc.typeArticle

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