A comparison of the neuroablative effects of conventional and pulsed radiofrequency techniques
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2008
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Abstract
Objectives: To compare the neuroablative effects of pulsed radiofrequency (PRF) and conventional radiofrequency (CRF) techniques on the sciatic nerve, a peripheral nerve that includes motor, sensory, and autonomous fibers. Methods: The study consisted of 5 groups of 6 adult male Wistar rats. In the control group, no procedure was performed. In the sham group, electrode placement was the same as the other groups, but radiofrequency energy was not given to the rats. In the CRF40 group, 40°C CRF was applied to the rats for 90 seconds. In the CRF80 group, 80°C CRF was applied for 90 seconds. In the PRF group, the rats received 45 V PRF, which did not exceed 42°C for 240 seconds. Two days later, sciatic nerve samples were taken. All specimens were evaluated both with light and electron microscopy. Sciatic nerve morphology was analyzed to compare the effects of CRF and PRF. Kruskal-Wallis and Mann-Whitney U tests were used for comparing the means. Results: Minimal damage was observed in the control group, but damage increased in the sham group and became increasingly more distinct in the PRF, CRF40, and CRF80 groups. Discussion: Nerve tissues can be affected during any type of procedure, even during surgical applications. Our results suggest that PRF is less destructive than CRF for the peripheral nerves. However, this idea should also be investigated at the molecular level, and safety analysis should be performed for routine clinical practice. © 2008 by Lippincott Williams & Wilkins.
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Animals , Catheter Ablation , Dose-Response Relationship, Radiation , Male , Microscopy, Electron, Transmission , Neurofilament Proteins , Radio Waves , Rats , Rats, Wistar , Sciatic Nerve , neurofilament protein , animal experiment , animal model , animal tissue , article , clinical practice , control group , controlled study , electrode , electron microscopy , electron probe microanalysis , energy , intermethod comparison , Kruskal Wallis test , male , microscopy , nerve injury , nervous tissue , nonhuman , peripheral nerve , priority journal , radiofrequency ablation , rank sum test , rat , sciatic nerve , surgical technique , temperature , Wistar rat , animal , catheter ablation , comparative study , metabolism , methodology , pathology , radiation exposure , radiation response , radiofrequency radiation , sciatic nerve , transmission electron microscopy , ultrastructure