The myeloprotective effect of medroxyprogesterone acetate in an irradiated animal model

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dc.contributor.authorSarper B.C.
dc.contributor.authorKurtman C.
dc.contributor.authorOzbilgin M. Kemal
dc.date.accessioned2024-07-22T08:24:50Z
dc.date.available2024-07-22T08:24:50Z
dc.date.issued2003
dc.description.abstractIn this study we evaluated the effect of medroxyprogesterone acetate (MPA) and its major ingredients on protection of the hematopoietic organs against radiation damage. Method: One group of mice was given saline as placebo and the other groups were given MPA. Mice were injected with MPA (10 mg/kg) or saline 10 days before or after a single 8 Gy whole body cobalt irradiation. On day 14 the mice were sacrificed and their bone marrow transplanted to recipient mice. Ten days after the transplantation, spleen colony formation was investigated in mice. Results: Administration of MPA with irradiation increased the formation of the spleen colony. Statistically significant enhancement of the spleen colony formation was found in mice treated with MPA repeatedly, as compared with those treated with placebo (P < 0.001). No significant difference in Spleen Colony Forming Unit (CFU-S) numbers was observed between pre-and post-radiotherapy administration of MPA (P= 0.216). Conclusion: It is an important observation that no significant difference was observed in CFU-S numbers between pre- and post-irradiation administration of MPA. © 2003 Foundation for Promotion of Cancer Research.
dc.identifier.DOI-ID10.1093/jjco/hyg122
dc.identifier.issn14653621
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20151
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAnimals
dc.subjectBone Marrow Cells
dc.subjectColony-Forming Units Assay
dc.subjectHematopoiesis
dc.subjectMale
dc.subjectMedroxyprogesterone 17-Acetate
dc.subjectMice
dc.subjectMice, Inbred C3H
dc.subjectModels, Animal
dc.subjectRadiation Injuries, Experimental
dc.subjectRadiation-Protective Agents
dc.subjectSpleen
dc.subjectWhole-Body Irradiation
dc.subjectcobalt
dc.subjectmedroxyprogesterone acetate
dc.subjectplacebo
dc.subjectsodium chloride
dc.subjectmedroxyprogesterone acetate
dc.subjectradioprotective agent
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectbone marrow suppression
dc.subjectbone marrow transplantation
dc.subjectcolony forming unit S
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectmale
dc.subjectnonhuman
dc.subjectradiation injury
dc.subjectradiation protection
dc.subjectrecipient
dc.subjectstatistical analysis
dc.subjectwhole body radiation
dc.subjectanimal
dc.subjectbone marrow cell
dc.subjectC3H mouse
dc.subjectclonogenic assay
dc.subjectcytology
dc.subjecthematopoiesis
dc.subjectmouse
dc.subjectradiation exposure
dc.subjectradiation injury
dc.subjectspleen
dc.titleThe myeloprotective effect of medroxyprogesterone acetate in an irradiated animal model
dc.typeArticle

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