A novel radiolabeled graft polymer: Investigation of the radiopharmaceutical potential using Albino Wistar rats
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Date
2019
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Abstract
Fe3O4 magnetic graft-Lys-poly(HEMA) was synthesized, labeled with 99mTc for the first time and its radiopharmaceutical potential was investigated using animal models in this study. Quality control procedures were carried out using thin layer radiochromatography. The labeling yield of radiolabeled polymer was found to be about 100%. Then, stability and lipophilicity were determined. The lipophilicity of 99mTc labeled Fe3O4 graft-Lys-poly(HEMA) was found to be 3.77. The serum stability experiments demonstrated that approximately 100% of radiolabeled polymer existed as an intact complex in the rat serum within 240 min. Biodistribution of radiolabeled magnetic graft-Lys-poly(HEMA) was performed on female Albino Wistar rats by scintigraphy and biodistribution studies. High uptake was seen in the stomach, the pancreas, brain, ovarian, intestines and the breast. © 2019 Elsevier Ltd
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Animals , Drug Stability , Female , Magnetite Nanoparticles , Male , Microscopy, Electron, Scanning , Organotechnetium Compounds , Polyhydroxyethyl Methacrylate , Polymers , Radiopharmaceuticals , Rats , Rats, Wistar , Tissue Distribution , Amino acids , Chromatography , Iron oxides , Magnetite , Nanoparticles , Nuclear medicine , Polymers , Rats , Technetium compounds , polymacon , technetium 99m , magnetite nanoparticle , polymacon , polymer , radiopharmaceutical agent , technetium complex , Biodistributions , Control procedures , Grafted polymers , HEMA , l-Lysine , Lipophilicity , Radiochromatography , Serum stability , animal experiment , animal tissue , Article , brain , breast , controlled study , drug blood level , drug distribution , drug stability , drug synthesis , drug tissue level , female , intestine , isotope labeling , lipophilicity , male , nonhuman , nuclear pharmacy , ovary , pancreas , priority journal , quality control procedures , rat , scintigraphy , stomach , Wistar rat , animal , chemistry , scanning electron microscopy , synthesis , tissue distribution , ultrastructure , Grafting (chemical)