Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database

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dc.contributor.authorAvouac J.
dc.contributor.authorWalker U.
dc.contributor.authorTyndall A.
dc.contributor.authorKahan A.
dc.contributor.authorMatucci-Cerinic M.
dc.contributor.authorAllanore Y.
dc.contributor.authorMiniati I.
dc.contributor.authorMüller A.
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dc.contributor.authorGiacomelli R.
dc.contributor.authorDistler O.
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dc.contributor.authorGorska I.Z.
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dc.contributor.authorWollheim F.
dc.contributor.authorMartinovic D.
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dc.contributor.authorJablonska S.
dc.contributor.authorReich K.
dc.contributor.authorBombardieri S.
dc.contributor.authorSiakka P.
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dc.contributor.authorBambara L.M.
dc.contributor.authorMorovic-Vergles J.
dc.contributor.authorDenton C.
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dc.contributor.authorVan Den Hoogen F.
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dc.contributor.authorKötter I.
dc.contributor.authorOrtiz V.
dc.contributor.authorHeitmann S.
dc.contributor.authorKrasowska D.
dc.contributor.authorSeidel M.
dc.contributor.authorHasler P.
dc.contributor.authorVan Laar J.M.
dc.contributor.authorKaltwasser J.P.
dc.contributor.authorFoeldvari I.
dc.contributor.authorJuan Mas A.
dc.contributor.authorBajocchi G.
dc.contributor.authorWislowska M.
dc.contributor.authorPereira Da Silva J.A.
dc.contributor.authorJacobsen S.
dc.contributor.authorWorm M.
dc.contributor.authorGraniger W.
dc.contributor.authorKuhn A.
dc.contributor.authorStankovic A.
dc.contributor.authorCossutta R.
dc.contributor.authorMajdan M.
dc.contributor.authorRajcevska L.D.
dc.contributor.authorTikly M.
dc.contributor.authorNasonov E.L.
dc.contributor.authorSteinbrink K.
dc.contributor.authorHerrick A.
dc.contributor.authorMüller-Ladner U.
dc.contributor.authorDinc A.
dc.contributor.authorScorza R.
dc.contributor.authorSondergaard K.
dc.contributor.authorIndiveri F.
dc.contributor.authorNielsen H.
dc.contributor.authorSzekanecz Z.
dc.contributor.authorSilver R.M.
dc.contributor.authorAntivalle M.
dc.contributor.authorEspinosa I.B.
dc.contributor.authorGarcía De La Pena Lefebvre P.
dc.contributor.authorMidtvedt O.
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dc.contributor.authorWigley F.
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dc.contributor.authorDistler J.H.
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dc.contributor.authorAringer M.
dc.contributor.authorWesthovens R.
dc.contributor.authorBellisai F.
dc.contributor.authorMayer M.
dc.contributor.authorStoeckl F.
dc.contributor.authorÜprus M.
dc.contributor.authorVolpe A.
dc.contributor.authorBuslau M.
dc.contributor.authorYavuz S.
dc.contributor.authorGranel B.
dc.contributor.authorFeijó A.V.
dc.contributor.authorDel Galdo F.
dc.contributor.authorPopa S.
dc.contributor.authorZenone T.
dc.contributor.authorMachado X.R.
dc.contributor.authorPileckyte M.
dc.contributor.authorStebbings S.
dc.contributor.authorMathieu A.
dc.contributor.authorTulli A.
dc.contributor.authorTourinho T.
dc.contributor.authorSouza R.
dc.contributor.authorAcayaba De Toledo R.
dc.contributor.authorStamp L.
dc.contributor.authorSolanki K.
dc.contributor.authorVeale D.
dc.contributor.authorNeto J.F.M.
dc.contributor.authorBagnato G.F.
dc.contributor.authorLoyo E.
dc.contributor.authorToloza S.
dc.contributor.authorLi M.
dc.contributor.authorMohamed W.A.A.A.
dc.contributor.authorCobankara V.
dc.contributor.authorOlas J.
dc.contributor.authorSalsano F.
dc.contributor.authorOksel F.
dc.contributor.authorTanaseanu C.M.
dc.contributor.authorFoti R.
dc.contributor.authorAncuta C.
dc.contributor.authorVonk M.
dc.contributor.authorCaramashi P.
dc.contributor.authorBeretta L.
dc.contributor.authorBalbir A.
dc.contributor.authorShine B.
dc.contributor.authorChiàla A.
dc.contributor.authorSimic K.P.
dc.contributor.authorGhio M.
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dc.contributor.authorHachulla E.
dc.contributor.authorFurst D.E.
dc.date.accessioned2024-07-22T08:20:49Z
dc.date.available2024-07-22T08:20:49Z
dc.date.issued2010
dc.description.abstractObjective. To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc). Methods. This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs. Results. We recruited 7286 patients with SSc; their mean age was 56 ± 14 years, disease duration 10 ± 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable. Conclusion. Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with amore severe disease and with systemic inflammation. The Journal of Rheumatology Copyright © 2010. All rights reserved.
dc.identifier.DOI-ID10.3899/jrheum.091165
dc.identifier.issn0315162X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18341
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAdult
dc.subjectAged
dc.subjectClinical Trials as Topic
dc.subjectCross-Sectional Studies
dc.subjectDatabases, Factual
dc.subjectFemale
dc.subjectHumans
dc.subjectInflammation
dc.subjectJoint Diseases
dc.subjectJoints
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRange of Motion, Articular
dc.subjectScleroderma, Localized
dc.subjectScleroderma, Systemic
dc.subjectSynovitis
dc.subjectTendons
dc.subjectadult
dc.subjectarticle
dc.subjectclinical feature
dc.subjectcohort analysis
dc.subjectdata base
dc.subjectdisease activity
dc.subjectdisease duration
dc.subjectechography
dc.subjectfemale
dc.subjecthand radiography
dc.subjecthuman
dc.subjectinflammation
dc.subjectinterstitial lung disease
dc.subjectjoint contracture
dc.subjectjoint radiography
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnuclear magnetic resonance imaging
dc.subjectpriority journal
dc.subjectrheumatic disease
dc.subjectscleroderma
dc.subjectskin disease
dc.subjectsynovitis
dc.subjectsystemic sclerosis
dc.subjecttenosynovitis
dc.titleCharacteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database
dc.typeArticle

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