Decreased maternal serum cortistatin levels in pregnancies with gestational diabetes mellitus

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dc.contributor.authorAkbas M.
dc.contributor.authorKoltan S.O.
dc.contributor.authorKoyuncu F.M.
dc.contributor.authorArtunc Ulkumen B.
dc.contributor.authorTaneli F.
dc.contributor.authorOzdemir H.
dc.date.accessioned2024-07-22T08:07:38Z
dc.date.available2024-07-22T08:07:38Z
dc.date.issued2020
dc.description.abstractObjective: To investigate serum cortistatin levels in women with gestational diabetes mellitus (GDM) and women with uncomplicated pregnancies. Material and methods: This case-control study consisted of 40 pregnancies with GDM and 41 healthy singleton pregnancies matched for maternal and gestational age. The maternal serum levels of cortistatin were measured with enzyme-linked immunosorbent assay and compared between groups. Results: Cortistatin levels were significantly lower in GDM group (48.85 ± 20.18 versus 65.84 ± 33.98 ng/ml, p =.008). There was a statistically significant difference in cortistatin levels between different treatment modalities and control group (χ2(2) = 8.828, p =.012). Pairwise comparisons showed that diet group had significantly lower CST levels than control group (p =.012). Serum cortistatin levels were negatively correlated with serum insulin and glucose levels and HOMA-IR (r = −0.358, p =.001; r = −0.303, p =.006; r = −0.444, p <.001, respectively). Conclusion: Cortistatin levels were significantly lower in GDM pregnancies and related to serum insulin and glucose levels and HOMA-IR in pregnancy. This may help to better clarify the mechanism of GDM pathogenesis. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.DOI-ID10.1080/14767058.2019.1627321
dc.identifier.issn14767058
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14037
dc.language.isoEnglish
dc.publisherTaylor and Francis Ltd
dc.subjectAdult
dc.subjectBlood Glucose
dc.subjectCase-Control Studies
dc.subjectDiabetes, Gestational
dc.subjectFemale
dc.subjectHumans
dc.subjectInsulin Resistance
dc.subjectNeuropeptides
dc.subjectPregnancy
dc.subjectYoung Adult
dc.subjectcortistatin
dc.subjectglucose
dc.subjectcortistatin
dc.subjectneuropeptide
dc.subjectadult
dc.subjectArticle
dc.subjectcase control study
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcorrelational study
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectgestational age
dc.subjecthuman
dc.subjectinsulin resistance
dc.subjectmaternal age
dc.subjectmetabolic parameters
dc.subjectpregnancy
dc.subjectpregnancy diabetes mellitus
dc.subjectpriority journal
dc.subjectprotein blood level
dc.subjectblood
dc.subjectglucose blood level
dc.subjectpregnancy
dc.subjectpregnancy diabetes mellitus
dc.subjectyoung adult
dc.titleDecreased maternal serum cortistatin levels in pregnancies with gestational diabetes mellitus
dc.typeArticle

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