Predictive and prognostic factors in ovarian and uterine carcinosarcomas

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dc.contributor.authorCicin İ.
dc.contributor.authorÖzatlı T.
dc.contributor.authorTürkmen E.
dc.contributor.authorÖzturk T.
dc.contributor.authorÖzçelik M.
dc.contributor.authorÇabuk D.
dc.contributor.authorGökdurnalı A.
dc.contributor.authorBalvan Ö.
dc.contributor.authorYıldız Y.
dc.contributor.authorŞeker M.
dc.contributor.authorÖzdemir N.
dc.contributor.authorYapar B.
dc.contributor.authorTanrıverdi Ö.
dc.contributor.authorGünaydin Y.
dc.contributor.authorMenekşe S.
dc.contributor.authorÖksüzoğlu B.
dc.contributor.authorAksoy A.
dc.contributor.authorErdogan B.
dc.contributor.authorHacıoglu M.B.
dc.contributor.authorArpaci E.
dc.contributor.authorSevinç A.
dc.date.accessioned2024-07-22T08:11:33Z
dc.date.available2024-07-22T08:11:33Z
dc.date.issued2016
dc.description.abstractBackground: Prognostic factors and the standard treatment approach for gynaecological carcinosarcomas have not yet been clearly defined. Although carcinosarcomas are more aggressive than pure epithelial tumours, they are treated similarly. Serous/clear cell and endometrioid components may be predictive factors for the efficacy of adjuvant chemotherapy (CT) or radiotherapy (RT) or RT in patients with uterine and ovarian carcinosarcomas. Heterologous carcinosarcomas may benefit more from adjuvant CT. Aims: We aimed to define the prognostic and predictive factors associated with treatment options in ovarian (OCS) and uterine carcinosarcoma (UCS). Study Design: Retrospective cross-sectional study Methods: We retrospectively reviewed the medical records of patients with ovarian and uterine carcinosarcoma from 2000 to 2013, and 127 women were includ ed in this study (24 ovarian and 103 uterine). Patients admitted to seventeen oncology centres in Turkey between 2000 and December 2013 with a histologically proven diagnosis of uterine carcinosarcoma with FIGO 2009 stage I-III and patients with sufficient data obtained from well-kept medical records were included in this study. Stage IV tumours were excluded. The patient records were retrospectively reviewed. Data from 104 patients were evaluated for this study. Results: Age (≥70 years) was a poor prognostic factor for UCS (p=0.036). Pelvic±para aortic lymph node dissection did not affect overall survival (OS) (p=0.35). Macroscopic residual disease was related with OS (p<0.01). The median OS was significantly longer in stage I-II patients than stage III patients (p=0.03). Adjuvant treatment improved OS (p=0.013). Adjuvant radiotherapy tended to increase the median OS (p=0.075). However, this tendency was observed in UCS (p=0.08) rather than OCS (p=0.6).Adjuvant chemotherapy had no effect on OS (p=0.15).Adjuvant radiotherapy significantly prolonged the median OS in patients with endometrioid component (p=0.034). A serous/clear cell component was a negative prognostic factor (p=0.035). Patients with serous/clear cell histology for whom adjuvant chemotherapy was applied had significantly longer OS (p=0.019), and there was no beneficial effect of adjuvant radiotherapy (p=0.4). Adjuvant chemotherapy was effective in heterologous tumours (p=0.026). In multivariate analysis, the stage and chemotherapy were prognostic factors for all patients. Age was an independent prognostic factor for UCS. However, serous/clear cell histology and radiotherapy tended to be significant prognostic factors. Conclusion: The primary location, the histological type of sarcomatous and the epithelial component may be predictive factors for the efficacy of chemotherapy or radiotherapy in UCS and OCS. © Trakya University Faculty of Medicine.
dc.identifier.DOI-ID10.5152/balkanmedj.2016.151268
dc.identifier.issn21463123
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15694
dc.language.isoEnglish
dc.publisherAVES Ibrahim Kara
dc.rightsAll Open Access; Gold Open Access
dc.subjectantineoplastic agent
dc.subjectplatinum complex
dc.subjectadjuvant radiotherapy
dc.subjectadult
dc.subjectage
dc.subjectaged
dc.subjectArticle
dc.subjectbrachytherapy
dc.subjectcancer adjuvant therapy
dc.subjectcancer classification
dc.subjectcancer prognosis
dc.subjectcancer staging
dc.subjectcarcinosarcoma
dc.subjectchemoradiotherapy
dc.subjectclinical observation
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectdrug efficacy
dc.subjectfemale
dc.subjecthuman
dc.subjectlymph node dissection
dc.subjectmajor clinical study
dc.subjectmedical record review
dc.subjectminimal residual disease
dc.subjectovarian carcinosarcoma
dc.subjectovary cancer
dc.subjectoverall survival
dc.subjectparaaortic lymph node
dc.subjectpelvis lymph node
dc.subjectprediction
dc.subjectretrospective study
dc.subjectsurvival time
dc.subjecttumor localization
dc.subjectTurkey (republic)
dc.subjectuterine carcinosarcoma
dc.subjectuterus cancer
dc.titlePredictive and prognostic factors in ovarian and uterine carcinosarcomas
dc.typeArticle

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