Emergence of phenotypic resistance to ciprofloxacin and levofloxacin in methicillin-resistant and methicillin-sensitive Staphylococcus aureus strains

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dc.contributor.authorLimoncu M.H.
dc.contributor.authorErmertcan S.
dc.contributor.authorÇetin C.B.
dc.contributor.authorCosar G.
dc.contributor.authorDinç G.
dc.date.accessioned2024-07-22T08:25:03Z
dc.date.available2024-07-22T08:25:03Z
dc.date.issued2003
dc.description.abstractThe emergence of phenotypic resistance to ciprofloxacin and levofloxacin in methicillin-sensitive and methicillin-resistant Staphylococcus aureus (MRSA) strains was studied. Twenty MRSA and 77 methicillin-sensitive S.aureus (MSSA) strains susceptible to both quinolones were investigated for resistance after single step or serial passages. No growth of 20 MRSA strains was observed at 4×MIC of levofloxacin after 48 h incubation, but 4 of 77 (5%) MSSA strains grew at the same concentration. At 4×MIC concentration of ciprofloxacin, 10 MSSA (13%) and five MRSA (25%) strains were grown. In the serial passages of MRSA strains, resistance to ciprofloxacin was 75 and 5% for levofloxacin by the third passage. In the seventh passage this resistance was 100 and 15%, respectively. In MSSA strains, resistance to ciprofloxacin was 75 and 19% to levofloxacin at the third passage and at the seventh passage, 100 and 61%, respectively. Emergence of ciprofloxacin resistance was more common and developed more rapidly than resistance to levofloxacin in both MRSA and MSSA strains. © 2003 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.
dc.identifier.DOI-ID10.1016/S0924-8579(03)00006-2
dc.identifier.issn09248579
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20249
dc.language.isoEnglish
dc.publisherElsevier
dc.subjectciprofloxacin
dc.subjectlevofloxacin
dc.subjectquinoline derived antiinfective agent
dc.subjectantibiotic resistance
dc.subjectantibiotic sensitivity
dc.subjectarticle
dc.subjectbacterial growth
dc.subjectbacterial strain
dc.subjectbacterium culture
dc.subjectconcentration response
dc.subjectcontrolled study
dc.subjectincubation time
dc.subjectmethicillin resistant Staphylococcus aureus
dc.subjectminimum inhibitory concentration
dc.subjectnonhuman
dc.subjectphenotype
dc.subjectpriority journal
dc.titleEmergence of phenotypic resistance to ciprofloxacin and levofloxacin in methicillin-resistant and methicillin-sensitive Staphylococcus aureus strains
dc.typeArticle

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