Bile duct response to repeated cerulein induced pancreatitis in the rat

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dc.contributor.authorMenteş A.
dc.contributor.authorAydede H.
dc.contributor.authorBayol Ü.
dc.contributor.authorYilmaz F.
dc.date.accessioned2024-07-22T08:25:17Z
dc.date.available2024-07-22T08:25:17Z
dc.date.issued2002
dc.description.abstractThe typical morphology of common bile duct strictures in chronic pancreatitis suggests a pathogenesis not of encasement, but of mural changes in the common bile duct. Cerulein, 20 μg/kg was administered to male Wistar rats in four subcutaneous doses, hourly for 3 h, and was recorded as one application. Group A served as controls and received subcutaneous saline. Group B1 received one application of Cerulein and was sacrificed after 24 h. Group B2 was similar to B1, but was sacrificed two weeks later. Group B3 was given two applications of Cerulein with an interval of two weeks and was sacrificed two weeks after the second application. Group B4 received one application of Cerulein every week for four weeks and was sacrificed two weeks after the last application. Serum amylase levels, pancreatic edema and peripancreatic inflammatory infiltration scores increased with the severity and persistance of the insult. Bilirubin and alkaline phosphatase levels suggested cholestatic response in the groups that received repeated insults with Cerulein (Groups B3 and B4: p < 0.01). Moderate to strong immuno-histochemical positivity for type IV collagen at the wall of the common bile duct in animals with a persisting insult is suggestive of circumstantial evidence for mural changes as a causative factor of stricture formation in similar settings such as chronic pancreatitis with persistent inflammatory attacks.
dc.identifier.issn13000144
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20361
dc.language.isoEnglish
dc.subjectInfiltration
dc.subjectMorphology
dc.subjectPhosphates
dc.subjectProteins
dc.subjectalanine aminotransferase
dc.subjectalkaline phosphatase
dc.subjectamylase
dc.subjectaspartate aminotransferase
dc.subjectbilirubin
dc.subjectceruletide
dc.subjectcollagen type 4
dc.subjectsodium chloride
dc.subjectalkaline phosphatase blood level
dc.subjectamylase blood level
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectbile duct obstruction
dc.subjectbilirubin blood level
dc.subjectblood sampling
dc.subjectcontrolled study
dc.subjectdisease severity
dc.subjectenzyme blood level
dc.subjecthistopathology
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectnonhuman
dc.subjectpancreatitis
dc.subjectrat
dc.subjectBile duct
dc.subjectDiseases
dc.titleBile duct response to repeated cerulein induced pancreatitis in the rat
dc.typeArticle

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