Identifying Clinical Characteristics of Hypoparathyroidism in Turkey: HIPOPARATURK-NET Study

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dc.contributor.authorKonca Degertekin C.
dc.contributor.authorGogas Yavuz D.
dc.contributor.authorPekkolay Z.
dc.contributor.authorSaygili E.
dc.contributor.authorUgur K.
dc.contributor.authorOr Koca A.
dc.contributor.authorUnubol M.
dc.contributor.authorTopaloglu O.
dc.contributor.authorAydogan B.I.
dc.contributor.authorOzdemir Kutbay N.
dc.contributor.authorHekimsoy Z.
dc.contributor.authorYilmaz N.
dc.contributor.authorBalci M.K.
dc.contributor.authorTanrikulu S.
dc.contributor.authorAydogan Unsal Y.
dc.contributor.authorErsoy C.
dc.contributor.authorOmma T.
dc.contributor.authorKeskin M.
dc.contributor.authorYalcin M.M.
dc.contributor.authorYetkin I.
dc.contributor.authorSoylu H.
dc.contributor.authorKarakose M.
dc.contributor.authorYilmaz M.
dc.contributor.authorKarakilic E.
dc.contributor.authorPiskinpasa H.
dc.contributor.authorBatman A.
dc.contributor.authorAkbaba G.
dc.contributor.authorElbuken G.
dc.contributor.authorTura Bahadir C.
dc.contributor.authorKilinc F.
dc.contributor.authorBilginer M.C.
dc.contributor.authorTurhan Iyidir O.
dc.contributor.authorCanturk Z.
dc.contributor.authorAktas Yilmaz B.
dc.contributor.authorSayiner Z.A.
dc.contributor.authorEroglu M.
dc.date.accessioned2024-07-22T08:04:44Z
dc.date.available2024-07-22T08:04:44Z
dc.date.issued2022
dc.description.abstractHypoparathyroidism is an orphan disease with ill-defined epidemiology that is subject to geographic variability. We conducted this study to assess the demographics, etiologic distribution, treatment patterns and complication frequency of patients with chronic hypoparathyroidism in Turkey. This is a retrospective, cross-sectional database study, with collaboration of 30 endocrinology centers located in 20 cities across seven geographical regions of Turkey. A total of 830 adults (mean age 49.6 ± 13.5 years; female 81.2%) with hypoparathyroidism (mean duration 9.7 ± 9.0 years) were included in the final analysis. Hypoparathyroidism was predominantly surgery-induced (n = 686, 82.6%). The insulting surgeries was carried out mostly due to benign causes in postsurgical group (SG) (n = 504, 73.5%) while patients in nonsurgical group (NSG) was most frequently classified as idiopathic (n = 103, 71.5%). The treatment was highly dependent on calcium salts (n = 771, 92.9%), calcitriol (n = 786, 94.7%) and to a lower extent cholecalciferol use (n = 635, 76.5%) while the rate of parathyroid hormone (n = 2, 0.2%) use was low. Serum calcium levels were most frequently kept in the normal range (sCa 8.5–10.5 mg/dL, n = 383, 46.1%) which might be higher than desired for this patient group. NSG had a lower mean plasma PTH concentration (6.42 ± 5.53 vs. 9.09 ± 7.08 ng/l, p < 0.0001), higher daily intake of elementary calcium (2038 ± 1214 vs. 1846 ± 1355 mg/day, p = 0.0193) and calcitriol (0.78 ± 0.39 vs. 0.69 ± 0.38 mcg/day, p = 0.0057), a higher rate of chronic renal disease (9.7% vs. 3.6%, p = 0.0017), epilepsy (6.3% vs. 1.6%, p = 0.0009), intracranial calcifications (11.8% vs. 7.3%, p < 0.0001) and cataracts (22.2% vs. 13.7%, p = 0.0096) compared to SG. In conclusion, postsurgical hypoparathyroidism is the dominant etiology of hypoparathyroidism in Turkey while the nonsurgical patients have a higher disease burden with greater need for medications and increased risk of complications than the postsurgical patients. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
dc.identifier.DOI-ID10.1007/s00223-021-00908-2
dc.identifier.issn0171967X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12828
dc.language.isoEnglish
dc.publisherSpringer
dc.subjectAdult
dc.subjectCalcium
dc.subjectFemale
dc.subjectHumans
dc.subjectHypocalcemia
dc.subjectHypoparathyroidism
dc.subjectMiddle Aged
dc.subjectParathyroid Hormone
dc.subjectRetrospective Studies
dc.subjectTurkey
dc.subjectcalcitriol
dc.subjectcalcium salt
dc.subjectcolecalciferol
dc.subjectparathyroid hormone
dc.subjectcalcium
dc.subjectparathyroid hormone
dc.subjectadult
dc.subjectArticle
dc.subjectbrain calcification
dc.subjectcalcium intake
dc.subjectcataract
dc.subjectchronic kidney failure
dc.subjectclinical feature
dc.subjectcross-sectional study
dc.subjectdata base
dc.subjectDiGeorge syndrome
dc.subjectepilepsy
dc.subjectfemale
dc.subjecthuman
dc.subjecthypoparathyroidism
dc.subjectidiopathic hypoparathyroidism
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectpostoperative complication
dc.subjectretrospective study
dc.subjectthalassemia
dc.subjectTurkey (republic)
dc.subjecthypocalcemia
dc.subjecthypoparathyroidism
dc.subjectturkey (bird)
dc.titleIdentifying Clinical Characteristics of Hypoparathyroidism in Turkey: HIPOPARATURK-NET Study
dc.typeArticle

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