Risk factors for radiation failure in early-stage glottic carcinoma: A systematic review and meta-analysis

Simple item page
dc.contributor.authorEskiizmir G.
dc.contributor.authorBaskın Y.
dc.contributor.authorYalçın F.
dc.contributor.authorEllidokuz H.
dc.contributor.authorFerris R.L.
dc.date.accessioned2024-07-22T08:11:44Z
dc.date.available2024-07-22T08:11:44Z
dc.date.issued2016
dc.description.abstractBackground Radiotherapy is one of the main treatment modalities for early-stage glottic carcinoma. Unfortunately, local failure may occur in a group of cases with T1-T2 glottic carcinoma. This meta-analysis sought to determine risk factors for radiation failure in patients with early-stage glottic carcinoma. Methods A systematic and comprehensive search was performed for related studies published between 1995 and 2014. The primary end-point was 5-year local control. Data extraction and analysis were performed using the software STATA/SE 13.1 for Windows. Results Twenty-seven studies were eligible. A higher risk of radiation failure was demonstrated in male patients [relative risk (RR): 0.927, p < 0.001] and those with low hemoglobin level (RR: 0.891, p < 0.001) with a high agreement between studies (I-squared = 0.0%). Moreover, T2 tumors (RR: 0.795, p < 0.001), tumors with anterior commissure involvement (RR: 0.904, p < 0.001), tobacco use during/after therapy (RR: 0.824, p < 0.001), and “bulky” tumors (RR: 1.270, p < 0.001] or tumors bigger in size (RR: 1.332, p < 0.001]. Poorly differentiated tumors had a questionable risk of local failure, although a moderate to high interstudy heterogeneity was determined. A statistically significant contribution was not detected for age, presence of comorbidity, alcohol use or subglottic extension. Conclusion This is the first meta-analysis which assessed the potential risk factors for radiation failure in patients with early-stage glottic carcinoma. Gender and pretreatment hemoglobin level are major influential factors associated with radiation failure in patients with early-stage glottic carcinoma. However, prospective, randomized clinical trials may permit better stratification of their relative contributions, and those who may benefit more from upfront surgery. © 2016
dc.identifier.DOI-ID10.1016/j.oraloncology.2016.10.013
dc.identifier.issn13688375
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15767
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.subjectAdult
dc.subjectAged
dc.subjectFemale
dc.subjectGlottis
dc.subjectHumans
dc.subjectLaryngeal Neoplasms
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRisk Factors
dc.subjecthemoglobin
dc.subjectalcohol consumption
dc.subjectanterior commissure
dc.subjectArticle
dc.subjectcancer radiotherapy
dc.subjectcancer size
dc.subjectcancer staging
dc.subjectcomorbidity
dc.subjectearly cancer
dc.subjectgroups by age
dc.subjecthemoglobin blood level
dc.subjecthuman
dc.subjectlarynx carcinoma
dc.subjectmeta analysis
dc.subjectpersonalized medicine
dc.subjectpriority journal
dc.subjectradiation injury
dc.subjectrisk factor
dc.subjectsex difference
dc.subjectsystematic review
dc.subjecttobacco use
dc.subjecttreatment failure
dc.subjecttumor differentiation
dc.subjecttumor microenvironment
dc.subjectadult
dc.subjectaged
dc.subjectfemale
dc.subjectglottis
dc.subjectlarynx tumor
dc.subjectmale
dc.subjectmiddle aged
dc.subjectpathology
dc.titleRisk factors for radiation failure in early-stage glottic carcinoma: A systematic review and meta-analysis
dc.typeArticle

Files

Collections

Scopus Koleksiyonu