Renal cell carcinoma: assessment of key pathologic prognostic parameters and patient characteristics in 47 909 cases using the National Cancer Data Base

Simple item page
dc.contributor.authorNese N.
dc.contributor.authorPaner G.P.
dc.contributor.authorMallin K.
dc.contributor.authorRitchey J.
dc.contributor.authorStewart A.
dc.contributor.authorAmin M.B.
dc.date.accessioned2024-07-22T08:21:52Z
dc.date.available2024-07-22T08:21:52Z
dc.date.issued2009
dc.description.abstractOn the basis of the National Cancer Data Base (NCDB), we describe the disease characteristics and use of conventional prognostic parameters in a hospital-based cohort of pathologically confirmed renal cell carcinomas (RCCs). Between 1993 and 1998, the NCDB obtained 149 424 cases of kidney (and renal pelvis) cancers from registries all over the United States. This database was queried for 47 909 histologically specified RCCs. Survival outcome was analyzed based on conventional clinical and pathologic parameters reported to the database (up to 2003). Renal cell carcinoma was more common in men (male-female ratio = 1.6:1). The mean age was 62.6 years. Most (66.6%) were organ-confined (stage I/II) at the time of diagnosis. The mean tumor size was 6.49 cm. The 5-year observed survival of RCC was 62.9% for male and 68.1% for female and was 81.0% for younger than 40 years old and 64.2% for older than 40 years old. The 5-year observed survival of RCC patients by the fifth edition 1997 American Joint Committee on Cancer TNM staging were stages I, 77.8%; II, 72.8%; III, 55.0%; and IV, 16.9%, demonstrating a dramatic decline in patient survival at stage IV. By reported pathologic grade, significant stratification was achieved in the observed survival for RCC overall irrespective of histologic subtypes (grade 1, 77.8%; 2, 69.6%; 3, 48.8%; and 4, 35.3% 5-year observed survival). These large NCDB data in RCC confirm the importance of pathologic evaluation of traditional prognostic parameters of stage and grade in RCC and is a powerful resource in defining cancer patient characteristics and analysis of prognostic variables that helps influence future cancer care planning and resource allocation. © 2009 Elsevier Inc. All rights reserved.
dc.identifier.DOI-ID10.1016/j.anndiagpath.2008.10.002
dc.identifier.issn10929134
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18812
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAdult
dc.subjectCarcinoma, Renal Cell
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCohort Studies
dc.subjectDatabases, Factual
dc.subjectDisease-Free Survival
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant
dc.subjectKidney Neoplasms
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasm Staging
dc.subjectUnited States
dc.subjectYoung Adult
dc.subjectadult
dc.subjectarticle
dc.subjectcancer center
dc.subjectcancer diagnosis
dc.subjectcancer grading
dc.subjectcancer patient
dc.subjectcancer staging
dc.subjectdata base
dc.subjectfemale
dc.subjectgroups by age
dc.subjecthistology
dc.subjecthuman
dc.subjectkidney carcinoma
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectresource allocation
dc.subjectsurvival rate
dc.subjecttumor volume
dc.subjectUnited States
dc.titleRenal cell carcinoma: assessment of key pathologic prognostic parameters and patient characteristics in 47 909 cases using the National Cancer Data Base
dc.typeArticle

Files

Collections

Scopus Koleksiyonu