Tumor Budding Should Be in Oral Cavity Cancer Reporting: A Retrospective Cohort Study Based on Tumor Microenvironment

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dc.contributor.authorTan A.
dc.contributor.authorTaskin T.
dc.date.accessioned2024-07-22T08:02:37Z
dc.date.available2024-07-22T08:02:37Z
dc.date.issued2023
dc.description.abstractThe utility of histological grading, which is useful in predicting prognosis in many tumors, is controversial for oral squamous cell carcinoma (OSCC). Therefore, new histopathological parameters should be added to histopathology reports of OSCCs. The study aimed to evaluate the parameters of worst invasion pattern (WPOI) and tumor budding in patients with OSCC, to compare them with other histopathological parameters, clinical data and overall survival, and to evaluate these results within the literature. A total of 73 OSCC cases with excisional biopsies were included in this study. WPOI, tumor budding, cell nest size, tumor-stroma ratio, stromal lymphocyte infiltration and stroma type, as well as classical histopathological parameters, were evaluated on hematoxylin-eosin-stained sections. Perineural invasion, lymph node metastases, advanced stage, presence of more than five buds and single cell invasion pattern in univariate survival analyses are characterized by a shortened overall survival time. While there was no significant difference between WPOI results and survival in the survival analysis, WPOI 5 was associated with more frequent lymph node metastasis and advanced stage at the time of diagnosis compared to WPOI 4. We concluded that tumor budding and single-cell invasion should be considered prognostic histopathologic parameters in OSCC. © 2023 by the authors.
dc.identifier.DOI-ID10.3390/cancers15153905
dc.identifier.issn20726694
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11933
dc.language.isoEnglish
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjecteosin
dc.subjecthematoxylin
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectcancer diagnosis
dc.subjectcancer grading
dc.subjectcancer patient
dc.subjectcancer prognosis
dc.subjectcancer survival
dc.subjectcell budding
dc.subjectcell invasion
dc.subjectcell nest size
dc.subjectcell size
dc.subjectclinical practice
dc.subjectcohort analysis
dc.subjectdiagnosis time
dc.subjectevaluation study
dc.subjectexcisional biopsy
dc.subjectfemale
dc.subjectfollow up
dc.subjecthealth care utilization
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectinformation processing
dc.subjectlymph node metastasis
dc.subjectlymphocytic infiltration
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectmouth cancer
dc.subjectmouth squamous cell carcinoma
dc.subjectoncological parameters
dc.subjectoverall survival
dc.subjectpatient care
dc.subjectperineural invasion
dc.subjectretrospective study
dc.subjectstaining
dc.subjectstroma cell
dc.subjectsurvival analysis
dc.subjectsurvival time
dc.subjecttumor budding
dc.subjecttumor microenvironment
dc.subjecttumor stroma ratio
dc.subjectunivariate analysis
dc.subjectworst invasion pattern
dc.titleTumor Budding Should Be in Oral Cavity Cancer Reporting: A Retrospective Cohort Study Based on Tumor Microenvironment
dc.typeArticle

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