Remote organ injury induced by myocardial ischemia and reperfusion on reproductive organs, and protective effect of melatonin in male rats

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dc.contributor.authorSahna E.
dc.contributor.authorTürk G.
dc.contributor.authorAtessahin A.
dc.contributor.authorYilmaz S.
dc.contributor.authorOlmez E.
dc.date.accessioned2024-07-22T08:22:51Z
dc.date.available2024-07-22T08:22:51Z
dc.date.issued2007
dc.description.abstractObjective: Myocardial ischemia and reperfusion (MI-R) leads to remote organ injury associated with oxidative stress. Melatonin is a well-known antioxidant and free-radical scavenger. This study was conducted to examine whether MI-R causes damage in the testes and sperm quality, and to investigate the possible protective effect of exogenous melatonin on these parameters in an in vivo rat model. Design: Experimental study. Setting: Experimental Research Center, Fi{dotless}rat University Medical School, Elazi{dotless}ǧ, Turkey. Patient(s): Eight-week-old male Wistar rats (n = 18). Intervention(s): To produce MI-R, a branch of the descending left coronary artery was occluded for 30 minutes, followed by 120-minute reperfusion. Melatonin (10 mg/kg) or vehicle was given 10 minutes before ischemia via the jugular vein. Main Outcome Measure(s): Reproductive organ weights and epididymal sperm concentration, sperm motility, abnormal sperm rate, and testicular-tissue malondialdehyde (MDA) and glutathione (GSH) levels were examined after reperfusion. Result(s): MI-R significantly decreased epididymal sperm motility, and increased the testes-tissue level of MDA, compared to the control group. Administration of melatonin reversed the harmful effects of MI-R significantly. However, MI-R did not change sperm concentration, GSH levels, and reproductive organ weights. Conclusion(s): These findings indicate that MI-R leads to damage of testis tissue and sperm motility, and melatonin protects against MI-R-induced reproductive-organ injury. These results may also encourage the use of antioxidants to reduce remote organ injury in the testis after MI-R. © 2007 American Society for Reproductive Medicine.
dc.identifier.DOI-ID10.1016/j.fertnstert.2006.11.068
dc.identifier.issn00150282
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19269
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAnimals
dc.subjectGenitalia, Male
dc.subjectMale
dc.subjectMelatonin
dc.subjectMyocardial Ischemia
dc.subjectMyocardial Reperfusion Injury
dc.subjectProtective Agents
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectantioxidant
dc.subjectglutathione
dc.subjectmalonaldehyde
dc.subjectmelatonin
dc.subjectscavenger
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectcoronary artery
dc.subjectdisease association
dc.subjectdrug effect
dc.subjectheart muscle ischemia
dc.subjectheart muscle reperfusion
dc.subjectin vivo study
dc.subjectjugular vein
dc.subjectleft coronary artery
dc.subjectmale
dc.subjectnonhuman
dc.subjectorgan injury
dc.subjectoxidative stress
dc.subjectpriority journal
dc.subjectrat
dc.subjectsingle drug dose
dc.subjectsperm
dc.subjectspermatozoon motility
dc.subjecttestis
dc.subjecttestis injury
dc.subjectTurkey (republic)
dc.subjectWistar rat
dc.titleRemote organ injury induced by myocardial ischemia and reperfusion on reproductive organs, and protective effect of melatonin in male rats
dc.typeArticle

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