Hormone receptor expressions and proliferation markers in postmenopausal endometrial polyps

Simple item page
dc.contributor.authorInceboz U.S.
dc.contributor.authorNese N.
dc.contributor.authorUyar Y.
dc.contributor.authorOzcakir H.T.
dc.contributor.authorKurtul O.
dc.contributor.authorBaytur Y.B.
dc.contributor.authorKandiloglu A.R.
dc.contributor.authorCaglar H.
dc.contributor.authorFraser I.S.
dc.date.accessioned2024-07-22T08:23:41Z
dc.date.available2024-07-22T08:23:41Z
dc.date.issued2006
dc.description.abstractBackground/Aims: Endometrial polyps are quite common in the general population, they have a significant role in postmenopausal bleeding, and the pathogenesis is unclear. The aim of this study was to investigate proliferation markers and expression of estrogen and progesterone receptors in endometrial polyps in postmenopausal women. Methods: Endometrial polyps were removed by hysteroscopy from 36 women who presented with postmenopausal bleeding. None were using hormonal therapy. The control group consisted of 16 inactive-atrophic postmenopausal endometrial specimens removed at hysterectomy. Immunohistochemistry was used to demonstrate expression of estrogen and progesterone receptors and the cell growth and apoptosis markers, Ki67, bcl-2, c-erbB-2. Results: In both the glandular epithelium and stroma of endometrial polyps, estrogen and progesterone receptors, Ki67 and bcl-2 showed significantly more positive staining than the inactive endometrium from the control group. There was no difference in expression of c-erbB-2 between the two groups. Conclusions: Estrogen may have a role in the development of postmenopausal endometrial polyps, either by direct stimulation of localized proliferation or by stimulation of proliferation via other pathways, such as activation of Ki67 or through inhibition of apoptosis via bcl-2. c-erbB-2 is unlikely to play any role in development of these lesions. Copyright © 2006 S. Karger AG.
dc.identifier.DOI-ID10.1159/000088018
dc.identifier.issn03787346
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19651
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCase-Control Studies
dc.subjectEndometrium
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectKi-67 Antigen
dc.subjectMiddle Aged
dc.subjectPolyps
dc.subjectPostmenopause
dc.subjectProto-Oncogene Proteins c-bcl-2
dc.subjectReceptor, erbB-2
dc.subjectReceptors, Estrogen
dc.subjectReceptors, Progesterone
dc.subjectTreatment Outcome
dc.subjectTumor Markers, Biological
dc.subjectUterine Diseases
dc.subjectepidermal growth factor receptor 2
dc.subjectestrogen receptor
dc.subjectKi 67 antigen
dc.subjectprogesterone receptor
dc.subjectprotein bcl 2
dc.subjectapoptosis
dc.subjectarticle
dc.subjectcell growth
dc.subjectcell proliferation
dc.subjectclinical article
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectdisease marker
dc.subjectendometrium polyp
dc.subjectestrogen activity
dc.subjectfemale
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjecthysteroscopy
dc.subjectimmunohistochemistry
dc.subjectmenopause related disorder
dc.subjectpostmenopause
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjecttissue section
dc.titleHormone receptor expressions and proliferation markers in postmenopausal endometrial polyps
dc.typeArticle

Files

Collections

Scopus Koleksiyonu