The role of circadian rhythm genes in cancer; [Kanserde sirkadiyan ritim genlerinin rolü]

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dc.contributor.authorAtmaca H.
dc.contributor.authorUzunoǧlu S.
dc.date.accessioned2024-07-22T08:19:58Z
dc.date.available2024-07-22T08:19:58Z
dc.date.issued2011
dc.description.abstractCircadian (In Latin: Circa=around, Diem=day) rhythm describes the processes of 24 hour oscillations in the living systems. At the cellular level, circadian rhythm is controlled by a molecular network with positive and negative feedbacks. The known critical elements in the positive feedback loop are Clock and Bmal1; the ones in complementary negative feedback are mainly Period and Cryptochrome genes. In cancer, which is an important health problem today, dysregulation of circadian rhythm is an important risk factor. In this review, circadian rhythm genes involved in cell proliferation, apoptosis, DNA repair, metabolism, detoxification and response to DNA damage and their roles in cancer development are summarized.
dc.identifier.issn13033546
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17934
dc.language.isoEnglish
dc.subjectapoptosis
dc.subjectcancer growth
dc.subjectcarcinogenesis
dc.subjectcell proliferation
dc.subjectcircadian rhythm
dc.subjectcircadian rhythm gene
dc.subjectdetoxification
dc.subjectDNA damage
dc.subjectDNA repair
dc.subjectgene function
dc.subjectmalignant neoplastic disease
dc.subjectmetabolism
dc.subjectoncogene
dc.subjectreview
dc.titleThe role of circadian rhythm genes in cancer; [Kanserde sirkadiyan ritim genlerinin rolü]
dc.typeReview

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