Relationship between circulating IGF-1 levels and traumatic brain injury-induced hippocampal damage and cognitive dysfunction in immature rats

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dc.contributor.authorOzdemir, D
dc.contributor.authorBaykara, B
dc.contributor.authorAksu, I
dc.contributor.authorKiray, M
dc.contributor.authorSisman, AR
dc.contributor.authorCetin, F
dc.contributor.authorDayi, A
dc.contributor.authorGurpinar, T
dc.contributor.authorUysal, N
dc.contributor.authorArda, MN
dc.date.accessioned2025-04-10T10:33:32Z
dc.date.available2025-04-10T10:33:32Z
dc.description.abstractIt is well known that traumatic brain injury (TBI) induces the cognitive dysfunction resulting from hippocampal damage. In the present study, we aimed to assess whether the circulating IGF-I levels are associated with cognition and hippocampal damage in 7-day-old rat pups subjected to contusion injury. Hippocampal damage was examined by cresyl violet staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Spatial memory performance was assessed in the Morris water maze. Serum IGF-1 levels decreased in both early and late period of TBI. Decreased levels of serum IGF-1 were correlated with hippocampal neuron loss and spatial memory deficits. Circulating IGF-1 levels may be predictive of cognitive dysfunction resulted from hippocampal damage following traumatic injury in developing brain. Therapy strategies that increase circulating IGF-1 may be highly promising for preventing the unfavorable outcomes of traumatic damage in young children. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.e-issn1872-7972
dc.identifier.issn0304-3940
dc.identifier.urihttp://hdl.handle.net/20.500.14701/39778
dc.language.isoEnglish
dc.titleRelationship between circulating IGF-1 levels and traumatic brain injury-induced hippocampal damage and cognitive dysfunction in immature rats
dc.typeArticle

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