Does remote ischemic preconditioning affect the systemic inflammatory response by modulating presepsin levels?

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dc.contributor.authorBayram B.
dc.contributor.authorSenarslan D.A.
dc.contributor.authorSengel A.
dc.contributor.authorOzturk T.
dc.contributor.authorOnur E.
dc.contributor.authorIskesen I.
dc.date.accessioned2024-07-22T08:01:50Z
dc.date.available2024-07-22T08:01:50Z
dc.date.issued2024
dc.description.abstractObjective: We investigated the effect of Remote Ischemic Preconditioning (RIPC) on the inflammatory response during CPB by means of serum presepsin levels at preoperative and postoperative 1st and 24th h. Methods: In this prospective, randomized, cross-sectional study we included 81 patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass (CPB). Patients were randomized and RIPC was applied to 40 patients in the study group before anesthesia. The remaining 41 patients were determined as the control group. The relationships between RIPC and factors such as presepsin, C-reactive protein (CRP), and leukocyte levels were investigated. Results: There was no significant difference between the groups in postoperative leukocyte and CRP values (p = 0.52, p = 0.13, respectively). When the preoperative and postoperative first hour presepsin values of the patients were compared, no significant difference was found in the control group (p = 0.17), but a significant difference was found in the study group (p < 0.05). When the presepsin values were compared between the groups, a significant difference was found only in the postoperative first hour value (p < 0.05). Conclusions: It was observed that RIPC application caused to increase the presepsin levels in the postoperative first hour significantly in the study group (p < 0.05). © The Author(s) 2024.
dc.identifier.DOI-ID10.1177/03913988241255495
dc.identifier.issn03913988
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11600
dc.language.isoEnglish
dc.publisherSAGE Publications Ltd
dc.subjectBio-chemical sensor
dc.subjectCardiac-surgery
dc.subjectCardiopulmonary bypass
dc.subjectControl groups
dc.subjectInflammation
dc.subjectInflammatory response
dc.subjectIschemic preconditioning
dc.subjectPresepsin
dc.subjectRemote ischemic preconditioning
dc.subjectStudy Groups
dc.subjectCardiovascular surgery
dc.titleDoes remote ischemic preconditioning affect the systemic inflammatory response by modulating presepsin levels?
dc.typeArticle

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