Implications of continuous positive airway pressure on heart rate variability in patients with obstructive sleep apnea: Does gender matter?; [Obstrüktif uyku apneli hastalarda sürekli pozitif havayolu basıncı tedavisinin kalp hızı değişkenliği üzerine etkisi: Cinsiyetin önemi nedir?]

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dc.contributor.authorÖzlek B.
dc.contributor.authorÖzlek E.
dc.contributor.authorDoğan V.
dc.contributor.authorBaşaran Ö.
dc.contributor.authorÇil C.
dc.contributor.authorÇelik O.
dc.contributor.authorBiteker M.
dc.contributor.authorBilge A.R.
dc.date.accessioned2024-07-22T08:08:18Z
dc.date.available2024-07-22T08:08:18Z
dc.date.issued2020
dc.description.abstractObjective: This study was designed to determine the effectiveness of continuous positive airway pressure (CPAP) treatment on the improvement of heart rate variability (HRV) and whether gender plays a role in HRV in patients with moderate to severe obstructive sleep apnea syndrome (OSAS). Methods: Consecutive patients with recently diagnosed moderate to severe OSAS underwent continuous synchronized electrocardiographic monitoring and were prospectively considered for inclusion in the study. HRV was analyzed before starting CPAP therapy and 1 year thereafter. The effects of CPAP on HRV were evaluated in men and women separately to ascertain whether there are gender differences in the clinical manifestations of OSAS and whether female HRV responses to CPAP are similar to those of men. Results: A total of 18 patients (10 men, median age: 56 years) were included in the study. There were no significant differences in the baseline clinical characteristics of the male and female patients. After 1 year of CPAP treatment, heart rate decreased (p<0.05) and time domain parameters increased (p<0.05) in both men and women. None of the frequency domain parameters changed in women (p>0.05), whereas the high frequency power measured increased (p<0.05) and the ratio of low frequency to high frequency decreased (p<0.05) in men after 1 year of CPAP treatment. The increase in HRV after 1 year of CPAP therapy was significantly higher in men than in women (p<0.05). Conclusion: CPAP therapy reduced enhanced cardiac sympathetic nerve activity in patients with OSAS assessed according to HRV. The beneficial effect of long-term CPAP therapy on HRV was more pronounced in men. © 2020 Turkish Society of Cardiology.
dc.identifier.DOI-ID10.5543/tkda.2019.66247
dc.identifier.issn10165169
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14337
dc.language.isoEnglish
dc.publisherTurkish Society of Cardiology
dc.rightsAll Open Access; Gold Open Access
dc.subjectAged
dc.subjectArrhythmias, Cardiac
dc.subjectContinuous Positive Airway Pressure
dc.subjectFemale
dc.subjectGender Identity
dc.subjectHeart Rate
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectSleep Apnea, Obstructive
dc.subjectadult
dc.subjectArticle
dc.subjectautonomic dysfunction
dc.subjectclinical article
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectdisease severity
dc.subjectelectrocardiography monitoring
dc.subjectfemale
dc.subjectheart rate variability
dc.subjectHolter monitoring
dc.subjecthuman
dc.subjectmale
dc.subjectmiddle aged
dc.subjectpositive end expiratory pressure
dc.subjectprospective study
dc.subjectsex difference
dc.subjectsleep disordered breathing
dc.subjectaged
dc.subjectgender identity
dc.subjectheart arrhythmia
dc.subjectheart rate
dc.subjectpathophysiology
dc.subjectpositive end expiratory pressure ventilation
dc.subjectsleep disordered breathing
dc.titleImplications of continuous positive airway pressure on heart rate variability in patients with obstructive sleep apnea: Does gender matter?; [Obstrüktif uyku apneli hastalarda sürekli pozitif havayolu basıncı tedavisinin kalp hızı değişkenliği üzerine etkisi: Cinsiyetin önemi nedir?]
dc.typeArticle

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