The effect of Paracetamol exposure on hepatic and renal tissues during statin usage

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dc.contributor.authorAksun S.
dc.contributor.authorGökcimen A.
dc.contributor.authorKahyaoglu F.
dc.contributor.authorDemirci B.
dc.date.accessioned2024-07-22T08:09:12Z
dc.date.available2024-07-22T08:09:12Z
dc.date.issued2019
dc.description.abstractObjective: Statins and Paracetamol have widespread use in clinic and both drugs possess similar side effects; therefore, we investigated if drug-interaction occurs when the combination of these two drugs is used during therapy. Materials and methods: A total of 32 (12-15 months old) grown-up male rats were divided into four groups: Control group, RSV group (10 mg/kg Rosuvastatin/daily), APAP group (50 mg/kg Paracetamol/5 days/weekly), RSV + APAP (10 mg/kg Rosuvastatin/daily + 50 mg/kg Paracetamol/5 days/weekly). At the end of 8 weeks of chronic treatment, the blood and tissue samples were taken under the Ketamine and Xylasine anesthesia (50 mg/kg and 5 mg/kg, respectively). Results: In the liver, sinusoidal dilatations, pyknotic nuclei and hemorrhagic foci are more frequently seen in the group receiving combination therapy; although serum liver functions among groups were not significantly different. Kidney histopathologic alterations in APAP and RSV + APAP groups were found more distinct than in RSV alone group. Inducible nitric oxide synthase activity was highly increased with combination therapy in liver and kidney tissues. Conclusion: RSV-Paracetamol interaction may occur as an important drug interaction histopathologically even before it is manifested biochemically in the clinic. © 2019 De Gruyter. All rights reserved.
dc.identifier.DOI-ID10.1515/tjb-2018-0252
dc.identifier.issn02504685
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14727
dc.language.isoEnglish
dc.publisherDe Gruyter
dc.rightsAll Open Access; Gold Open Access
dc.subjectalbumin
dc.subjectinducible nitric oxide synthase
dc.subjectnitric oxide
dc.subjectparacetamol
dc.subjectrosuvastatin
dc.subjecturea
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcell structure
dc.subjectcolorimetry
dc.subjectcontrolled study
dc.subjectdrug exposure
dc.subjectenzyme activity
dc.subjectenzyme linked immunosorbent assay
dc.subjecthistopathology
dc.subjectimmunohistochemistry
dc.subjectkidney function
dc.subjectkidney hemorrhage
dc.subjectliver function
dc.subjectliver necrosis
dc.subjectmale
dc.subjectnonhuman
dc.subjectrat
dc.subjecttissue degeneration
dc.titleThe effect of Paracetamol exposure on hepatic and renal tissues during statin usage
dc.typeArticle

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