Clinical significance of low transaminase levels in children with inflammatory bowel disease

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dc.contributor.authorCakir M.
dc.contributor.authorSag E.
dc.contributor.authorDogan G.
dc.contributor.authorUnal F.
dc.contributor.authorKasirga E.
dc.date.accessioned2024-07-22T08:08:52Z
dc.date.available2024-07-22T08:08:52Z
dc.date.issued2019
dc.description.abstractBackground: Low alanine aminotransaminase (LALT) levels may be seen in patients with inflammatory bowel disease (IBD), but there has been no study about the frequency and its clinical significance. We aimed to analyze the frequency of LALT, and its clinical significance in children with IBD. Methods: The study included the 89 patients with IBD without hepatobiliary involvement. LALT was defined as ALT levels < 5 U/L. Demographic and clinical findings and outcome of the patients with and without LALT were compared. Results: LALT was found 47.1% of the patients. At initial examination, it was more common in female patients (92.3 vs. 41.3%, P < 0.001) and patients with CD (57.7 vs. 30.2%, P = 0.01). 75% of the patients with penetrating Crohn’s disease (CD) had LALT (P = 0.002). Hemoglobin (10.4 ± 2.1 vs. 11.7 ± 1.9 g/dL, P = 0.01), folic acid (5.2 ± 3.3 vs. 8.6 ± 5.9 ng/mL, P = 0.02) and serum albumin levels (3.6 ± 0.8 vs. 4.7 ± 5 g/dL, P = 0.002) were significantly low in patients with LALT. LALT was associted with the disease relapse within 2 weeks in 12 of the 16 patients with LALT whereas it was seen in 16 of the 73 patients without LALT during the follow-up (75 vs. 21.9%, P < 0.001). Additionally, steroid dependency was more common in patients with LALT during the follow-up (62.5 vs. 12.3%, P < 0.001). Conclusions: LALT is common in children with IBD especially in CD and associated with low hemoglobin, albumin and folic acid levels. It may be a marker of relapse and steroid dependency. © 2019, Children's Hospital, Zhejiang University School of Medicine.
dc.identifier.DOI-ID10.1007/s12519-019-00235-5
dc.identifier.issn17088569
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14566
dc.language.isoEnglish
dc.publisherInstitute of Pediatrics of Zhejiang University
dc.subjectAdolescent
dc.subjectAlbumins
dc.subjectBiomarkers
dc.subjectBlood Chemical Analysis
dc.subjectChild
dc.subjectCohort Studies
dc.subjectColitis, Ulcerative
dc.subjectCrohn Disease
dc.subjectDisease Progression
dc.subjectFolic Acid
dc.subjectHemoglobins
dc.subjectHumans
dc.subjectInflammatory Bowel Diseases
dc.subjectRecurrence
dc.subjectRetrospective Studies
dc.subjectRisk Assessment
dc.subjectSensitivity and Specificity
dc.subjectSeverity of Illness Index
dc.subjectTransaminases
dc.subjectalanine aminotransferase
dc.subjectalbumin
dc.subjectfolic acid
dc.subjecthemoglobin
dc.subjectsteroid
dc.subjectalbuminoid
dc.subjectaminotransferase
dc.subjectbiological marker
dc.subjectfolic acid
dc.subjecthemoglobin
dc.subjectadolescent
dc.subjectadult
dc.subjectalanine aminotransferase level
dc.subjectalbumin blood level
dc.subjectArticle
dc.subjectchild
dc.subjectchildhood disease
dc.subjectCrohn disease
dc.subjectfemale
dc.subjectfolic acid blood level
dc.subjecthemoglobin blood level
dc.subjecthuman
dc.subjectinfant
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnutritional status
dc.subjectsex difference
dc.subjectsteroid therapy
dc.subjectstunting
dc.subjectulcerative colitis
dc.subjectunderweight
dc.subjectblood
dc.subjectblood analysis
dc.subjectclinical trial
dc.subjectcohort analysis
dc.subjectcomparative study
dc.subjectCrohn disease
dc.subjectdisease exacerbation
dc.subjectinflammatory bowel disease
dc.subjectmetabolism
dc.subjectmulticenter study
dc.subjectpathophysiology
dc.subjectrecurrent disease
dc.subjectretrospective study
dc.subjectrisk assessment
dc.subjectsensitivity and specificity
dc.subjectseverity of illness index
dc.subjectulcerative colitis
dc.titleClinical significance of low transaminase levels in children with inflammatory bowel disease
dc.typeArticle

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