The preventive effect of N-acetylcysteine on radiation-induced dermatitis in a rat model

dc.contributor.authorDemirel, C
dc.contributor.authorKilciksiz, S
dc.contributor.authorEvirgen-Ayhan, S
dc.contributor.authorGurgul, S
dc.contributor.authorErdal, N
dc.date.accessioned2025-04-10T10:34:33Z
dc.date.available2025-04-10T10:34:33Z
dc.description.abstractPurpose: We investigated the potential radioprotective effects of N-acetylcysteine (NAG) comparing its effects with that of amifostine (WR-2721), as a representative of clinically used radioprotecor, in ameliorating skin injury from irradiation in rats (single dose, 18 Gy to the left hind legs of the rats). Methods: The rats (n=28) were divided randomly and equally into 4 groups: Control (C), Radiation (R), R+WR-2721 (received irradiation and 200 mg/kg of WR-2721) and R+NAC (received irradiation and 1000 mg/kg of NAG). Acute skin reactions were assessed every 3 days by a radiation oncologist and a biophysicist. Light microscopic findings were assessed by an expert pathologist. Results: Clinically and histopathologically, irradiation increased dermatitis when compared with the control group (p<0.05). The severity of radiodermatitis of the rats in the R+NAC and R+WR-2721 groups was significantly lower than in the R group (p<0.05). The protective effects of NAC and WR-2721 on irradiation increased dermatitis were clinically and histopathologically similar (p>0.05). Conclusion: The study gives clues about the beneficial effects of NAC against radiation-induced dermatitis.
dc.identifier.e-issn2241-6293
dc.identifier.issn1107-0625
dc.identifier.urihttp://hdl.handle.net/20.500.14701/40683
dc.language.isoEnglish
dc.titleThe preventive effect of N-acetylcysteine on radiation-induced dermatitis in a rat model
dc.typeArticle

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