Jak-Stat signaling pathway may play a role in the pathogenesis of cholesteatoma

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dc.contributor.authorEskiizmir G.
dc.contributor.authorSeda Vatansever H.
dc.contributor.authorÖzgür E.
dc.contributor.authorAslan A.
dc.contributor.authorTanyeri G.
dc.contributor.authorGözüaçik D.
dc.contributor.authorKemal Özbilgin M.
dc.contributor.authorCingi C.
dc.date.accessioned2024-07-22T08:16:30Z
dc.date.available2024-07-22T08:16:30Z
dc.date.issued2014
dc.description.abstractPurpose Jak-Stat signaling pathway is one of the major signal transduction cascades which regulates most of the cellular events such as cell proliferation, differentiation, cell migration and apoptosis. This study aims to determine the activity of Jak-Stat signaling pathway in the pathogenesis of cholesteatoma. Materials and Methods Cholesteatoma and skin samples were obtained from 10 patients who underwent tympanomastoidectomy for chronic otitis media with cholesteatoma. Immunohistochemical analysis of cholesteatoma and skin was performed using anti-Jak1, anti-Jak2, anti-Jak3, anti-Stat1, anti-Stat2, anti-Stat3, anti-Stat4 and anti-Stat5 antibodies. The immunoreactivities in cholesteatoma and skin were quantified using H-score measurement and statistical comparison was performed. Results Jak1, Jak2, Jak3, Stat1 and Stat3 immunoreactivities were not detected in cholesteatoma; in contrast to the skin (129.8; 226.7; 33.0; 66.4;115.9). In addition, when H-score measurements of Stat2, Stat4 and Stat5 immunoreactivities were compared between cholesteatoma (172.8; 166.7; 120.0) and skin (400.0; 284.9; 292.0), statistically significant differences were found (p < 0.0001, p < 0.0001, p < 0.0001). Conclusions A remarkable deficiency in the family members of Jak-Stat signaling pathway was demonstrated in cholesteatoma. Therefore, perturbations in Jak-Stat signaling pathway may play a role in the pathogenesis of cholesteatoma. © 2014 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.amjoto.2013.10.005
dc.identifier.issn1532818X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16853
dc.language.isoEnglish
dc.subjectApoptosis
dc.subjectBiological Markers
dc.subjectCell Proliferation
dc.subjectCholesteatoma, Middle Ear
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectJanus Kinases
dc.subjectSignal Transduction
dc.subjectenzyme antibody
dc.subjectjanus kinase 1 antibody
dc.subjectjanus kinase 2 antibody
dc.subjectjanus kinase 3 antibody
dc.subjectjanus kinase antibody
dc.subjectprotein antibody
dc.subjectstat 1 protein antibody
dc.subjectstat 2 protein antibody
dc.subjectstat 3 protein antibody
dc.subjectstat 4 protein antibody
dc.subjectstat 5 protein antibody
dc.subjectstat protein antibody
dc.subjectunclassified drug
dc.subjectcholesteatoma
dc.subjectchronic otitis media
dc.subjectclinical article
dc.subjectconference paper
dc.subjectcontrolled study
dc.subjecthuman
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectmastoidectomy
dc.subjectpathogenesis
dc.subjectpriority journal
dc.subjectsignal transduction
dc.subjectskin
dc.subjecttympanomastoidectomy
dc.titleJak-Stat signaling pathway may play a role in the pathogenesis of cholesteatoma
dc.typeConference paper

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