Multifunctional molecular imaging probes for estrogen receptors: 99mTc labeled diethylstilbestrol (DES) conjugated, cuinp quantum dot nanoparticles (DESCIP)

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dc.contributor.authorMoharrami P.
dc.contributor.authorUnak P.
dc.contributor.authorGuldu O.K.
dc.contributor.authorMedine E.I.
dc.contributor.authorGumuser G.
dc.contributor.authorBilgin E.S.
dc.contributor.authorAras O.
dc.date.accessioned2024-07-22T08:10:22Z
dc.date.available2024-07-22T08:10:22Z
dc.date.issued2017
dc.description.abstractA theranostic nanoparticle was synthesized based on diethylstilbestrol conjugated with phosphate, copper, and indium (DESCIP) and labelled with 99mTc which can be used for SPECT imaging of ER-enriched cancers. In vitro biological activity of 99mTc-DESCIP was examined in breast adenocarcinoma cells (MCF-7), prostatic carcinoma cells (PC-3), and pulmonary epithelial cells (A-549). In vivo lymph node imaging was performed in normal and receptor blocked female New Zealand rabbits. Results demonstrated that 99mTc-DESCIP and DESCIP has potential for imaging ER-enriched tumors such as breast and prostate tumors, and their metastases in the lung, as well as improving management for their therapies. © 2017, Akadémiai Kiadó, Budapest, Hungary.
dc.identifier.DOI-ID10.1007/s10967-017-5630-2
dc.identifier.issn02365731
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15200
dc.language.isoEnglish
dc.publisherSpringer Netherlands
dc.subjectdiethylstilbestrol
dc.subjectestrogen receptor
dc.subjectquantum dot
dc.subjecttechnetium 99m
dc.subjectA-549 cell line
dc.subjectanimal experiment
dc.subjectArticle
dc.subjectcellular distribution
dc.subjectcontrolled study
dc.subjectdrug cytotoxicity
dc.subjectdrug determination
dc.subjectdrug effect
dc.subjectfemale
dc.subjectin vivo study
dc.subjectisotope labeling
dc.subjectlipophilicity
dc.subjectmass spectrometry
dc.subjectMCF-7 cell line
dc.subjectmolecular imaging
dc.subjectNew Zealand rabbit
dc.subjectnonhuman
dc.subjectPC-3 [Human prostate carcinoma] cell line
dc.titleMultifunctional molecular imaging probes for estrogen receptors: 99mTc labeled diethylstilbestrol (DES) conjugated, cuinp quantum dot nanoparticles (DESCIP)
dc.typeArticle

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