Antimicrobial susceptibility of bacterial pathogens in the oropharynx of healthy school children in Turkey

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dc.contributor.authorGazi H.
dc.contributor.authorKurutepe S.
dc.contributor.authorSürüoǧlu S.
dc.contributor.authorTeker A.
dc.contributor.authorÖzbakkaloglǔ B.
dc.date.accessioned2024-07-22T08:24:19Z
dc.date.available2024-07-22T08:24:19Z
dc.date.issued2004
dc.description.abstractBackground & objectives: Information on oropharyngeal carriage rates of Streplococcus pneumoniae, Haemophilus influenzae, Streptococcus pyogenes and Moraxella catarrhalis and their resistance pattern in healthy school children in Turkey is lacking. The present study was undertaken to determine the carriage rates and antimicrobial resistance of these bacterial pathogens in such children aged 6-14 yr in Manisa, Turkey. Methods: A total of 1022 children were included from nine schools selected randomly from 32 schools. Throat swabs were cultured for bacteria which were identified using standard microbiological methods. Antimicrobial susceptibility was determined as per National Committee for Clinical Laboratory Standards guidelines. Results: Of the 1022 children 240 (23.4%) harboured S. pneumoniae, 162 (15.8%) H. influenzae, 30 (2.9%) S. pyogenes and 82 (8%) M. catarrhalis in their oropharynx. For S. pneumoniae overall 17.9 per cent of the isolates were intermediately and 7 per cent were resistant to penicillin and resistance to erythromycin trimethoprim-sulphamethoxasole (TMP/SMX), and chloramphenicol was 13.7, 9.1 and 1.6 per cent, respectively. Ampicillin resistance observed in 20.9 per cent of H. influenzae isolates was associated with the presence of β-lactamase, except two isolates interpreted as β-lactamase-negative ampicillin resistant strains. Resistance of H. influenzae to TMP/SMX, chloramphenicol, azithromycin, cefaclor and amoxicillin/clavulanic acid was 14.2, 2.4, 1.8, 1.2 and 1.2 per cent, respectively. M.catarrhalis isolates produced β-lactamase in 80.5 per cent of the cases and all were susceptible to macrolides and clavulanic acid/amoxicillin combination; the highest rate of resistance of 17 per cent was for TMP/SMX. One (3.3%) isolate of S. pyogenes was resistant to macrolides tested. Interpretation & conclusion: Our data shows that upper respiratory tract of about 50 per cent children was colonized with respiratory pathogens. There is a need for surveillance of nasopharyngeal carriage of resistant strains in healthy school children.
dc.identifier.issn09715916
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19925
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAnti-Bacterial Agents
dc.subjectBacteria
dc.subjectBacterial Infections
dc.subjectChild
dc.subjectDrug Resistance, Bacterial
dc.subjectHumans
dc.subjectMicrobial Sensitivity Tests
dc.subjectOropharynx
dc.subjectRandom Allocation
dc.subjectRespiratory Tract Infections
dc.subjectTurkey
dc.subjectamoxicillin plus clavulanic acid
dc.subjectampicillin
dc.subjectazithromycin
dc.subjectbeta lactamase
dc.subjectcefaclor
dc.subjectchloramphenicol
dc.subjectcotrimoxazole
dc.subjecterythromycin
dc.subjectmacrolide
dc.subjectpenicillin G
dc.subjectadolescent
dc.subjectantibiotic resistance
dc.subjectantibiotic sensitivity
dc.subjectarticle
dc.subjectbacterial colonization
dc.subjectbacterial strain
dc.subjectbacterium culture
dc.subjectbacterium identification
dc.subjectbacterium isolate
dc.subjectchild
dc.subjectchild care
dc.subjectcontrolled study
dc.subjectdisease carrier
dc.subjectHaemophilus influenzae
dc.subjecthuman
dc.subjectMoraxella catarrhalis
dc.subjectoropharynx
dc.subjectpenicillin resistance
dc.subjectpractice guideline
dc.subjectrandomization
dc.subjectStreptococcus pneumoniae
dc.subjectStreptococcus pyogenes
dc.subjectthroat culture
dc.subjectTurkey (republic)
dc.subjectupper respiratory tract
dc.titleAntimicrobial susceptibility of bacterial pathogens in the oropharynx of healthy school children in Turkey
dc.typeArticle

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