Determination of glycoconjugate residues of erythrocytes at different age groups of rats

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dc.contributor.authorGumus A.
dc.contributor.authorBalcan E.
dc.date.accessioned2024-07-22T08:21:14Z
dc.date.available2024-07-22T08:21:14Z
dc.date.issued2010
dc.description.abstractAging is a time-dependent process that contains cell injury caused by molecular damages and eventually functional impairment of tissues and organs. The possible roles of cell surface carbohydrates, which are very important molecules in cell to cell and/or cell to extracellular matrix recognition, on aging process are not yet clear. In this study, glycoconjugate alterations of membrane glycoproteins of erythrocytes in aging organism were evaluated with lectin histochemistry and lectin blotting studies in 1, 4 and 7 months old rats. Lectin histochemistry results indicated that α(2→3) and α(2→6)-linked sialic acids are intensively found in erythrocyte membranes, but this intensity of sialic acids decreases with age. Similar evidences were obtained from lectin blotting studies which performed with same lectins. These results suggest that sialic acid reactivity alters with the age of organism. We thought that (a) sialic acid containing glycoconjugates altered not only with erythrocyte senescence, but also aging process of organism or (b) the number of sialic acid containing erythrocytes decreased by age.
dc.identifier.DOI-ID10.4999/uhod.09070
dc.identifier.issn1306133X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18524
dc.language.isoEnglish
dc.publisherUHOD - Uluslararasi Hematoloji Onkoloji Dergisi
dc.rightsAll Open Access; Bronze Open Access
dc.subjectglycoconjugate
dc.subjectlectin
dc.subjectmembrane protein
dc.subjectsialic acid
dc.subjectadolescent
dc.subjectaged
dc.subjectaging
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcarbohydrate analysis
dc.subjectcell aging
dc.subjectcell surface
dc.subjectcontrolled study
dc.subjecterythrocyte membrane
dc.subjecthistochemistry
dc.subjectnonhuman
dc.subjectpolyacrylamide gel electrophoresis
dc.subjectprotein determination
dc.subjectrat
dc.titleDetermination of glycoconjugate residues of erythrocytes at different age groups of rats
dc.typeArticle

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