Effect of valproic acid treatment on penile structure in prepubertal rats

Simple item page
dc.contributor.authorKutlu Ö.
dc.contributor.authorCansu A.
dc.contributor.authorKaragüzel E.
dc.contributor.authorGürgen S.G.
dc.contributor.authorKoç Ö.
dc.contributor.authorGür M.
dc.contributor.authorÖzgür G.K.
dc.date.accessioned2024-07-22T08:19:28Z
dc.date.available2024-07-22T08:19:28Z
dc.date.issued2012
dc.description.abstractIntroduction: The aim of this study was to determine the histological effects of valproic acid (VPA) on the penis in prepubertal rats. Methods: Twelve male Wistar rats (21-24 days old) were divided equally into 2 experimental groups, and given tap water (control group) or 300. mg/kg/day VPA via gavage for 30 days. After the penes had been harvested, the antiangiogenic and antifibrogenic properties of VPA were evaluated immunohistochemically using vascular endothelial growth factor (VEGF), inducible nitric oxide synthase (iNOS), transforming growth factor-beta 1 (TGF-β1) and Masson's trichrome staining. Apoptosis was determined by caspase-3 and caspase-9 immunoreactions. Results were expressed as histochemical score (HSCORE), a semi-quantitative analysis for the intensity of immunohistochemical reactivity. Results: Immunohistochemical HSCORE decreased for VEGF and TGF-β1 staining and increased for iNOS staining in rats treated with VPA compared with the control group. Intensities of caspase-3 and caspase-9 labeling were also significantly increased by administration of VPA. Masson's trichrome staining exhibited a fairly diminished level of collagen in the corpus cavernosum of rats treated with VPA. Conclusion: In the light of these results, the administration of VPA from prepuberty to adulthood led to increased apoptosis and deterioration of the smooth muscle/collagen ratio in rat's corpus cavernosum. © 2011 Elsevier B.V.
dc.identifier.DOI-ID10.1016/j.eplepsyres.2011.12.010
dc.identifier.issn18726844
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17677
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectApoptosis
dc.subjectMale
dc.subjectPenis
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSexual Maturation
dc.subjectTreatment Outcome
dc.subjectValproic Acid
dc.subjectcaspase 3
dc.subjectcaspase 9
dc.subjectcollagen
dc.subjectinducible nitric oxide synthase
dc.subjecttransforming growth factor beta1
dc.subjectvalproic acid
dc.subjectvasculotropin
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectantibody labeling
dc.subjectapoptosis
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectcorpus cavernosum
dc.subjectdrug effect
dc.subjecthistopathology
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectmale
dc.subjectnonhuman
dc.subjectprepuberty
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectquantitative analysis
dc.subjectrat
dc.subjectscoring system
dc.subjectsmooth muscle fiber
dc.titleEffect of valproic acid treatment on penile structure in prepubertal rats
dc.typeArticle

Files

Collections

Scopus Koleksiyonu