Surface chemistry dependent toxicity of inorganic nanostructure glycoconjugates on bacterial cells and cancer cell lines

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dc.contributor.authorSancak S.
dc.contributor.authorYazgan İ.
dc.contributor.authorBayarslan A.U.
dc.contributor.authorAyna A.
dc.contributor.authorEvecen S.
dc.contributor.authorTaşdelen Z.
dc.contributor.authorGümüş A.
dc.contributor.authorSönmez H.A.
dc.contributor.authorDemir M.A.
dc.contributor.authorDemir S.
dc.contributor.authorBakar F.
dc.contributor.authorDilek-Tepe H.
dc.contributor.authorKasemets K.
dc.contributor.authorOtsus M.
dc.contributor.authorÇeter T.
dc.date.accessioned2024-07-22T08:03:43Z
dc.date.available2024-07-22T08:03:43Z
dc.date.issued2023
dc.description.abstractSurface functionalized nanostructures have outstanding potential in biological applications owing to their target-specific design. In this study, we utilized laboratory synthesized carbohydrate-derivatives (i.e., galactose, mannose, lactose, and cellobiose derivatives) for aqueous one-pot synthesis of gold (Au) and silver (Ag) nanostructure glycoconjugates (NSs), and iron metal-organic framework glycoconjugates (FeMOFs). This work aims to test whether differences in the surface chemistry of the inorganic nanostructures play roles in revealing their toxicities towards bacterial cells and cancerous cell lines. As of the first step, biological activity of AuNSs, AgNSs, and FeMOFs were tested against a variety of gram (−) and gram (+) bacterial strains, where AgNSs possessed moderate to high antibacterial activities against all the tested bacterial strains, while AuNSs and FeMOFs showed their bacterial toxicity mostly depending on the strain. Minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) determination studies were performed for the nanostructure glycoconjugates, for which μg/mL MBC values were obtained such as (Cellobiose p-aminobenzoic acid_AgNS) CBpAB_AgNS gave 50 μg/mL MBC value for P.aeruginosa and S.kentucy. The activity of selected sugar ligands and corresponding glycoconjugates were further tested on MDA-MB-231 breast cancer and A549 lung cancer cell lines, where selective anticancer activity was observed depending on the surface chemistry as well. Besides, D-penicillamine was introduced to galectin specific sugar ligand coated AuNS glycoconjugates, which showed very strong anticancer activities even at low doses. Overall, the importance of this work is that the surface chemistry of the inorganic nanostructures can be critical to reveal their toxicity towards bacterial cells and cancerous cell lines. © 2022 Elsevier B.V.
dc.identifier.DOI-ID10.1016/j.jddst.2022.104054
dc.identifier.issn17732247
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12403
dc.language.isoEnglish
dc.publisherEditions de Sante
dc.subject4 aminobenzoic acid
dc.subjectcarbohydrate derivative
dc.subjectcellobiose
dc.subjectgalactose
dc.subjectgalectin
dc.subjectglycoconjugate
dc.subjectgold nanoparticle
dc.subjectinorganic compound
dc.subjectiron
dc.subjectlactose
dc.subjectmannose
dc.subjectmetal organic framework
dc.subjectnanocarrier
dc.subjectnanomaterial
dc.subjectpenicillamine
dc.subjectprotein corona
dc.subjectsilver
dc.subjectsilver nanoparticle
dc.subjectA-549 cell line
dc.subjectantibacterial activity
dc.subjectantineoplastic activity
dc.subjectArticle
dc.subjectbacterial cell
dc.subjectbacterial growth
dc.subjectbacterial strain
dc.subjectbactericidal activity
dc.subjectcancer cell line
dc.subjectcontrolled study
dc.subjectcrystal structure
dc.subjectEnterobacter aerogenes
dc.subjectEnterococcus durans
dc.subjectEnterococcus faecium
dc.subjectEscherichia coli
dc.subjectfemale
dc.subjectflocculation
dc.subjectGram negative bacterium
dc.subjectGram positive bacterium
dc.subjecthuman
dc.subjecthuman cell
dc.subjectKlebsiella pneumoniae
dc.subjectMDA-MB-231 cell line
dc.subjectminimum bactericidal concentration
dc.subjectminimum inhibitory concentration
dc.subjectnonhuman
dc.subjectone pot synthesis
dc.subjectPseudomonas aeruginosa
dc.subjectSalmonella
dc.subjectSalmonella enterica serovar Enteritidis
dc.subjectSerratia marcescens
dc.subjectStaphylococcus aureus
dc.subjectStaphylococcus epidermidis
dc.subjectsurface property
dc.titleSurface chemistry dependent toxicity of inorganic nanostructure glycoconjugates on bacterial cells and cancer cell lines
dc.typeArticle

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