TGF-β1, neopterin, tetrahydrobiopterin, and nitric oxide levels in pediatric obsessive–compulsive disorder

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dc.contributor.authorÖzkan Y.
dc.contributor.authorKandemir H.
dc.contributor.authorSapmaz Ş.Y.
dc.contributor.authorTaneli F.
dc.date.accessioned2024-07-22T08:06:11Z
dc.date.available2024-07-22T08:06:11Z
dc.date.issued2021
dc.description.abstractThe biological mechanisms underlying obsessive–compulsive disorder (OCD) are not sufficiently elucidated. Chronic inflammation and oxidative stress were shown to increase neopterin and decrease tetrahydrobiopterin (BH4) levels by activating the neopterin–BH4 pathway. This study compared serum TGF-β1, TNF-α, IL-1β, IL-2, IL-6, IL-10, IL-17, neopterin, BH4, and nitric oxide (NO) levels between child and adolescent patients diagnosed with OCD and a healthy control group. The study included 29 patients diagnosed with OCD (comorbidity free, drug free) and 28 healthy children as an aged and sex matched control group. Serum samples were analyzed for TGF-β1, TNF-α, IL-1β, IL-2, IL-6, IL-10, IL-17, neopterin, and BH4 by using enzyme-linked immunosorbent assay method, and NO concentrations were assessed by colorimetric method based on Griess reaction. All cytokine levels were found to be low, but this decrease was statistically significant only for TGF-β1. The neopterin and NO levels were significantly higher and BH4 significantly lower in children with OCD compared to the healthy control group. Also, a statistically significant correlation was found between NO, neopterin, and BH4 levels. The results of our study show that the levels of TGF-β1 and NO and the activation of the neopterin–BH4 pathway may be implicated in the pathophysiology of OCD. © 2021 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.jocrd.2021.100649
dc.identifier.issn22113649
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13415
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.subjectinterleukin 10
dc.subjectinterleukin 17
dc.subjectinterleukin 1beta
dc.subjectinterleukin 2
dc.subjectinterleukin 6
dc.subjectneopterin
dc.subjectnitric oxide
dc.subjectsapropterin
dc.subjecttransforming growth factor beta1
dc.subjecttumor necrosis factor
dc.subjectadolescent
dc.subjectArticle
dc.subjectchild
dc.subjectclinical article
dc.subjectcolorimetry
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectdisease duration
dc.subjectdisease severity
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjecthuman
dc.subjectinflammation
dc.subjectmale
dc.subjectobsessive compulsive disorder
dc.subjectoxidative stress
dc.subjectpathophysiology
dc.subjectprotein blood level
dc.subjectsignal transduction
dc.titleTGF-β1, neopterin, tetrahydrobiopterin, and nitric oxide levels in pediatric obsessive–compulsive disorder
dc.typeArticle

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