A histological analysis of the protective effect of ischemic preconditioning in the rat retina

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dc.contributor.authorToprak A.B.
dc.contributor.authorOzbilgin K.
dc.contributor.authorToprak V.
dc.contributor.authorTuglu I.
dc.contributor.authorGuler C.
dc.date.accessioned2024-07-22T08:25:13Z
dc.date.available2024-07-22T08:25:13Z
dc.date.issued2002
dc.description.abstractPurpose. Ischemic preconditioning (IP) protects the retina from the damaging effect of subsequent ischemia in vivo. We aimed to investigate the histological alterations induced by the protective effect of IP to the retina. Methods. The eyes of the rats were rendered ischemic by intra-ocular pressure (IOP) elevation. IP procedure consisted of producing ischemia for 5 minutes. Sham operation was similar to IP procedure except the pressure elevation. The operational eyes of sham and IP group underwent 60 minutes of ischemia 24 hours after the first procedure. The eyes contralateral to the experimental eyes made up the control group. The eyes were histologically analysed one week after the ischemia. Results. The total retinal thickness of the sham group was significantly less than total retinal thickness of the control group (p < 0.001). There was not a significant difference between control and IP group regarding the total retinal thickness (p > 0.05). The thickness of the inner retinal layers of the sham group were significantly less than corresponding retinal layers of the control group (p < 0.001). The inner plexiform layer (IPL) and inner nuclear layer (INL) thickness values of the sham group were significantly less than same layers of the IP group (p < 0.001). Ganglion cell layer (GCL) thickness of the IP group was significantly less than GCL thickness of the control group (p < 0.001). IPL thickness of the IP group was significantly less than that of control group's (p < 0.05). The GCL and total retinal thickness of the IP group were significantly more than thickness of the corresponding layers of the sham group (p < 0.05). Conclusion. IP considerably protects inner retinal layers from subsequent ischemic damage in a high IOP ischemic model. This endogenous process could further be utilized to tailor specific neuroprotective strategies for retinal cells.
dc.identifier.DOI-ID10.1076/ceyr.24.3.234.8308
dc.identifier.issn02713683
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20324
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectControl Groups
dc.subjectIschemic Preconditioning
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectRetina
dc.subjectRetinal Ganglion Cells
dc.subjectRetinal Vessels
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcontrolled study
dc.subjecteye protection
dc.subjecthistology
dc.subjectintraocular pressure abnormality
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectretina ischemia
dc.subjectretina nerve cell
dc.subjectthickness
dc.titleA histological analysis of the protective effect of ischemic preconditioning in the rat retina
dc.typeArticle

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