Correlation of quality of life with clinical parameters and eosinophilic cation protein levels in children with allergic rhinoconjunctivitis

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dc.contributor.authorYuksel H.
dc.contributor.authorYilmaz O.
dc.contributor.authorSogut A.
dc.contributor.authorErtan P.
dc.contributor.authorOnur E.
dc.date.accessioned2024-07-22T08:22:10Z
dc.date.available2024-07-22T08:22:10Z
dc.date.issued2008
dc.description.abstractBackground: Systemic and mucosal roles of eosinophils in the pathogenesis of allergic rhinoconjunctivitis (AR) are known. The aim of this study was to investigate the relationship of clinical parameters and quality of life with eosinophilic cationic protein (ECP) in grass pollen-sensitive children with seasonal AR. Methods: This study included 31 children with AR and 18 healthy controls aged between 5 and 15 years. ECP levels in nasal lavage fluid and serum were measured. AR symptom scores were calculated and the pediatric rhinoconjunctivitis quality of life questionnaire (PRQLQ) was filled in for all patients. Results: Mean serum and nasal ECP levels (ng/ml) were significantly higher in the patient group (p < 0.05 for both). In the AR group, the mean clinical symptom score was 7.3 ± 2.2, while the total PRQLQ score, activity limitation, symptoms and emotional function domains were 2.5 ± 0.9, 3.0 ± 1.1, 2.5 ± 1.2 and 2.6 ± 1.1, respectively. The total clinical symptom score and disease duration showed a significant correlation with the total PRQLQ score (p = 0.00 and 0.003, respectively). However, neither nasal lavage nor serum ECP levels were significantly correlated with symptom score, duration of disease, PRQLQ total score or domains (p > 0.05 for all). Conclusion: These results may indicate the absence of a correlation between clinical status and quality of life and levels of ECP in tissues with allergic inflammation. Copyright © 2008 S. Karger AG.
dc.identifier.DOI-ID10.1159/000151501
dc.identifier.issn10182438
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18963
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectConjunctivitis, Allergic
dc.subjectEosinophil Cationic Protein
dc.subjectEosinophils
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectNasal Lavage Fluid
dc.subjectPollen
dc.subjectQuality of Life
dc.subjectQuestionnaires
dc.subjectRhinitis, Allergic, Seasonal
dc.subjecteosinophil cationic protein
dc.subjectadolescent
dc.subjectarticle
dc.subjectchild
dc.subjectclinical article
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectdisease duration
dc.subjectdisease severity
dc.subjectemotion
dc.subjectfemale
dc.subjecthay fever
dc.subjecthuman
dc.subjectmale
dc.subjectnose mucus
dc.subjectphysical activity
dc.subjectpriority journal
dc.subjectprotein blood level
dc.subjectquality of life
dc.subjectquestionnaire
dc.subjectscoring system
dc.titleCorrelation of quality of life with clinical parameters and eosinophilic cation protein levels in children with allergic rhinoconjunctivitis
dc.typeArticle

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