Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus

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dc.contributor.authorGur E.B.
dc.contributor.authorKaradeniz M.
dc.contributor.authorGenc M.
dc.contributor.authorEskicioglu F.
dc.contributor.authorYalcin M.
dc.contributor.authorHepyilmaz I.
dc.contributor.authorGuclu S.
dc.date.accessioned2024-07-22T08:13:45Z
dc.date.available2024-07-22T08:13:45Z
dc.date.issued2015
dc.description.abstractTo investigate whether vitamin D deficiency is associated with high mean platelet volume (MPV) in pregnancies diagnosed with gestational diabetes mellitus (GDM) compared to healthy pregnancies. Subjects and methods: This study included 200 pregnant women. 25-hydroxyvitamin D3 (25(OH)D3) and MPV values were monitored between pregnant women with GDM and normal glucose metabolism. Correlation between 25(OH)D3 and MPV was calculated both in GDM and healthy pregnancies. Both 25(OH)D3 level in different MPV percentile (≤ 50, 50-75, 75-90, ≥ 90 percentile) and MPV value in different 25(OH)D3 level (≤ 10, 10-20, ≥ 20 ng/mL) were calculated. Results: Low 25(OH) D3 level and high MPV were observed both in GDM group (p = 0.007, p = 0.06, respectively) and in glucose metabolism disorders (GMD) group (p = 0.03, p = 0.04, respectively).There was no significant relationship between 25(OH)D3 and MPV in healthy pregnancies. Whereas, it is observed that there is a negative, but statistically insignificant correlation between MPV and 25(OH)D3 pregnant women with GMD (r = 0.1, r = -0.7, respectively). MPV values had significantly higher in vitamin D deficient group than pregnant women with normal 25(OH)D3 level in GMD group (p = 0.04).The optimal 25(OH) D3 cut off point for predicting future cardiovascular risk was 10.4 ng/ mL (area under curve (AUC) = 0.58). Conclusions: Vitamin D deficiency may contribute to an increased risk for future cardiovascular diseases and a risk of thrombotic complications in pregnant women with GDM. © 2015, Sociedade Brasileira de Endocrinologia e Metabologia. All rights reserved.
dc.identifier.DOI-ID10.1590/2359-3997000000063
dc.identifier.issn23593997
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16399
dc.language.isoEnglish
dc.publisherSociedade Brasileira de Endocrinologia e Metabologia
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAdult
dc.subjectCardiovascular Diseases
dc.subjectDiabetes, Gestational
dc.subjectFemale
dc.subjectGlucose Tolerance Test
dc.subjectHumans
dc.subjectMean Platelet Volume
dc.subjectPregnancy
dc.subjectRisk Factors
dc.subjectROC Curve
dc.subjectVitamin D
dc.subjectVitamin D Deficiency
dc.subjectYoung Adult
dc.subject25-hydroxyvitamin D
dc.subjectvitamin D
dc.subjectadult
dc.subjectanalogs and derivatives
dc.subjectblood
dc.subjectCardiovascular Diseases
dc.subjectcomplication
dc.subjectfemale
dc.subjectglucose tolerance test
dc.subjecthuman
dc.subjectpregnancy
dc.subjectpregnancy diabetes mellitus
dc.subjectreceiver operating characteristic
dc.subjectrisk factor
dc.subjectthrombocyte volume
dc.subjectvitamin D deficiency
dc.subjectyoung adult
dc.titleRelationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus
dc.typeArticle

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