Fibrinogen-to-Albumin Ratio in Familial Mediterranean Fever: Association with Subclinical Inflammation

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dc.contributor.authorOnder E.N.A.
dc.contributor.authorErtan P.
dc.date.accessioned2024-07-22T08:05:26Z
dc.date.available2024-07-22T08:05:26Z
dc.date.issued2021
dc.description.abstractBackground Familial Mediterranean fever (FMF) is the most seen monogenic periodic fever syndrome characterised by bouts of fever and serositis. It is known that subclinical inflammation (SI) can persist in the symptom-free period and lead to amyloidosis even under colchicine treatment. This study aimed to evaluate the role of the fibrinogen-to-albumin ratio (FAR) in FMF and its correlation with SI. Material and Methods A total of 112 patients with FMF and 78 controls were enrolled in this retrospective study. Demo-Demographic, laboratory and genetic data were obtained from the hospital records. Results The FAR values of the FMF cases were significantly higher than the control group (p < 0.001). In the FMF group, the patients with SI had higher FAR values than those without SI (p < 0.001). FAR was positively correlated with SI (r = 0.413, p < 0.001). The receiver operating characteristic curve analysis showed that FAR had a higher area under the curve value than albumin and fibrinogen. Conclusion Detecting SI in patients with FMF is crucial in preventing amyloidosis, the most devastating complication of FMF. FAR is a simple, inexpensive, easily obtained indicator which can be used for reflecting SI in FMF. © 2020 American Institute of Physics Inc.. All rights reserved.
dc.identifier.DOI-ID10.1055/a-1610-9745
dc.identifier.issn03008630
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13139
dc.language.isoEnglish
dc.publisherGeorg Thieme Verlag
dc.subjectAlbumins
dc.subjectFamilial Mediterranean Fever
dc.subjectFibrinogen
dc.subjectHumans
dc.subjectInflammation
dc.subjectRetrospective Studies
dc.subjectalbumin
dc.subjectcolchicine
dc.subjectfibrinogen
dc.subjectalbuminoid
dc.subjectadult
dc.subjectamyloidosis
dc.subjectarea under the curve
dc.subjectArticle
dc.subjectchronic disease indicator
dc.subjectchronic inflammation
dc.subjectcontrol group
dc.subjectcontrolled study
dc.subjectdemography
dc.subjectdiagnostic test accuracy study
dc.subjectdiagnostic value
dc.subjectdisease association
dc.subjectdisease severity assessment
dc.subjectfamilial Mediterranean fever
dc.subjectfamily history
dc.subjectfemale
dc.subjectgene mutation
dc.subjectgenetic analysis
dc.subjectgenetic association
dc.subjecthuman
dc.subjecthypoalbuminemia
dc.subjectimmunosuppressive treatment
dc.subjectlaboratory diagnosis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmedical record
dc.subjectoutpatient department
dc.subjectperiod prevalence
dc.subjectprotein blood level
dc.subjectprotein function
dc.subjectreceiver operating characteristic
dc.subjectretrospective study
dc.subjectsubclinical inflammation
dc.subjectfamilial Mediterranean fever
dc.subjectgenetics
dc.subjectinflammation
dc.titleFibrinogen-to-Albumin Ratio in Familial Mediterranean Fever: Association with Subclinical Inflammation
dc.typeArticle

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