The comparison of insülin resistance, laboratory results and clinical factors in gestational diabetes mellitus patients with normal pregnant women without glucose intolerance; [Gestasyonel Diabetes Mellitus ve Normal Glukoz Toleransna Sahip Gebelerde nsülin Direnci, Laboratuvar Bulgular ve Klinik Faktörlerin Karşilaştirilmasi]

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dc.contributor.authorPala H.G.
dc.contributor.authorÖzalp Y.
dc.contributor.authorSaatli Gerçeklioglu G.
dc.contributor.authorYener A.S.
dc.contributor.authorUysal S.
dc.contributor.authorÖnvural A.
dc.date.accessioned2024-07-22T08:18:15Z
dc.date.available2024-07-22T08:18:15Z
dc.date.issued2013
dc.description.abstractObjective: To compare insulin resistance, laboratory results and clinical factors in gestational diabetes mellitus (GDM) patients with normal pregnant women without glucose intolerance. Material and Methods: 55 GDM patients and 50 normal pregnant women who were between 24th and 28th week of gestation included in this study. 25 patients who had not completed antenatal visits or had developed complications during pregnancy period were excluded from study. Statistical analysis was performed for the rest of 40 GDM and 40 normal pregnant women without glucose intolerance. Total cholesterol, triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL), HbAlc, glucose, insulin and c-peptide levels were measured between 24th-28th week of gestation after starvation in maternal blood sample which included into study. The relationship between these groups' measurements and the other established clinical-laboratory factors were investigated. Results: HbAlc, c-peptide, insulin, glucose, triglyceride and LDL levels were significantly higher in GDM patients compared with the group of patients with normal glucose tolerance. There was not significant difference in terms of total cholesterol and HDL levels. Calculated HOMA-IR score was significantly higher and c-peptide/insulin and c-peptide/glucose ratio were lower in GDM patients compared with the group of patients with normal glucose tolerance. Conclusion: It is accepted that increased maternal adipocyte and plasental hormones' effect aganist insulin combination had an important role in GDM pathogenesis. In this study; we ascertained that HOMA-IR was raised GDM probability 8 fold and showed that insulin resistance was one of the basic factor in GDM pathogenesis. Copyright © 2013 by Türkiye Klinikleri.
dc.identifier.issn13000306
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17249
dc.language.isoTurkish
dc.subjectC peptide
dc.subjectglucose
dc.subjecthemoglobin A1c
dc.subjecthigh density lipoprotein
dc.subjectinsulin
dc.subjectlow density lipoprotein
dc.subjecttriacylglycerol
dc.subjectarticle
dc.subjectblood sampling
dc.subjectcholesterol blood level
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectgestational age
dc.subjectglucose intolerance
dc.subjecthuman
dc.subjectinsulin resistance
dc.subjectlaboratory test
dc.subjectmajor clinical study
dc.subjectmaternal blood
dc.subjectpregnancy diabetes mellitus
dc.subjectpregnant woman
dc.subjectrisk factor
dc.subjectstarvation
dc.titleThe comparison of insülin resistance, laboratory results and clinical factors in gestational diabetes mellitus patients with normal pregnant women without glucose intolerance; [Gestasyonel Diabetes Mellitus ve Normal Glukoz Toleransna Sahip Gebelerde nsülin Direnci, Laboratuvar Bulgular ve Klinik Faktörlerin Karşilaştirilmasi]
dc.typeArticle

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