Serum Her-2/neu and survivin levels and their relationship to histological parameters in early-stage breast cancer
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Date
2007
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Abstract
This study was conducted to investigate the serum levels of her-2/neu and survivin in patients with early-stage breast cancer and their relationship with known histological parameters. Forty-one patients with early-stage breast cancer were investigated. Serum samples were collected from patients on their first admission before adjuvant chemotherapy, and from healthy controls. Serum her-2/neu and survivin levels were determined using an enzyme-linked immunosorbent assay. There was no difference in the levels of serum her-2/neu and survivin between the breast cancer patients and the control group. Serum her-2/neu concentration showed moderate correlations with disease stage and the Ki-67 level, and the serum survivin level showed a moderate correlation with progesterone receptor concentration. Serum levels of her-2/neu and survivin were not significantly related to age and histological parameters in patients with early-stage breast cancer. However, much research continues on the prognostic value of serum her-2/neu and survivin levels, and important new knowledge may ultimately emerge. Copyright © 2007 Cambridge Medical Publications.
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epidermal growth factor receptor 2 , Ki 67 antigen , progesterone receptor , survivin , adult , age , article , breast cancer , cancer adjuvant therapy , cancer chemotherapy , cancer staging , clinical article , controlled study , early cancer , enzyme linked immunosorbent assay , female , histopathology , human , human tissue , protein blood level