Chromatographic profile and antioxidant and enzyme inhibitory activity of Sideritis leptoclada: An endemic plant from Turkey

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dc.contributor.authorSarikurkcu C.
dc.contributor.authorOzer M.S.
dc.contributor.authorIstifli E.S.
dc.contributor.authorSahinler S.S.
dc.contributor.authorTepe B.
dc.date.accessioned2024-07-22T08:05:20Z
dc.date.available2024-07-22T08:05:20Z
dc.date.issued2021
dc.description.abstractSideritis species have been used for centuries for their antimicrobial, digestive, anti-ulcerogenic and anti-inflammatory properties. Therefore, in this study, it was aimed to evaluate the chemical composition, antioxidant and enzyme inhibitory activities of solvent extracts of S. leptoclada O. Schwarz & P.H. Davis, an endemic species. It was determined that methanol (MeOH) and water extracts contained high amounts of chlorogenic acid and verbascoside, while the ethyl acetate (EtOAc) extract contained high amounts of 4-hydroxybenzoic and vanilic acids. The water extract showed the highest antioxidant activity in almost all parameters. Inhibitory activity of the MeOH extract on tyrosinase was 1.04 mg/ml, which was the highest value in this experiment. On the other hand, in α-amylase inhibitory assay, the EtOAc extract showed an activity of 2.21 mg/ml. Docking analysis showed that verbascoside can be an effective tyrosinase and α-amylase inhibitory agent. © 2021 SAAB
dc.identifier.DOI-ID10.1016/j.sajb.2021.03.020
dc.identifier.issn02546299
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13076
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.rightsAll Open Access; Hybrid Gold Open Access
dc.subjectTurkey
dc.subjectacetate
dc.subjectantioxidant
dc.subjectendemic species
dc.subjectenzyme activity
dc.subjectmethanol
dc.subjectplant
dc.subjectplant extract
dc.subjectsolvent
dc.titleChromatographic profile and antioxidant and enzyme inhibitory activity of Sideritis leptoclada: An endemic plant from Turkey
dc.typeArticle

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