Can we manage the melanocytic lesions with peripheral globules according to the grade of dysplasia?

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dc.contributor.authorAvcı C.
dc.contributor.authorAkın G.
dc.contributor.authorLebe B.
dc.contributor.authorŞahin M.T.
dc.contributor.authorFetil E.
dc.date.accessioned2024-07-22T08:01:09Z
dc.date.available2024-07-22T08:01:09Z
dc.date.issued2024
dc.description.abstractBackground/Objectives: Although excision of melanocytic nevi with high-grade dysplasia is recommended by the World Health Organization (WHO), clinical studies investigating the approach based on the grading dysplasia of melanocytic lesions with peripheral globules (PGs) are lacking. We investigated the grades of dysplasia and their distinguishable dermoscopic and clinical features to provide accurate data for managing these lesions. Methods: We retrospectively classified histologically confirmed melanocytic lesions with PGs according to the 2018 WHO Classification of Skin Tumours criteria in a university hospital in Turkey. Dermoscopic features, lesions, and patient characteristics were recorded. Results: Sixty-six lesions of 56 patients were included. After classification, 9.1% (n: 6) of lesions were melanomas, 39.4% (n: 26) were high-grade dysplastic nevi, and 50% (n: 33) were low-grade dysplastic nevi (n: 33, 50%). There was one nevus with no dysplasia (n: 1, 1.5%). Univariate analysis revealed that ≥31 years of age, irregular shape of peripheral globules, black colour, total colour count, and maximum diameter of the lesion were associated with high-grade dysplasia and melanoma. In the multivariate analyses, ≥31 years of age (OR = 3.80, 95% CI, 1.17–12.37), irregular shape of peripheral globules (OR = 3.90, 95% CI, 1.15–13.2), and total colour count (OR = 3.21, 95% CI, 1.2–8.5) were significant predictive factors for the lesions with high-grade dysplasia and melanomas. Conclusions: To avoid the underdiagnosis of both melanomas and high-grade dysplastic nevi with PGs, the irregular shape of peripheral globules and multiple colours after the third decade may be useful in making an excision decision. The risk increases every 1-year increase in age. Excision is suggested for all melanocytic lesions with PGs for patients 60 years or older because of the high risk of melanoma and melanocytic nevus with high-grade dysplasia. © 2024 Australasian College of Dermatologists.
dc.identifier.DOI-ID10.1111/ajd.14261
dc.identifier.issn00048380
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11351
dc.language.isoEnglish
dc.publisherJohn Wiley and Sons Inc
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAge Factors
dc.subjectAged
dc.subjectDermoscopy
dc.subjectDysplastic Nevus Syndrome
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMelanoma
dc.subjectMiddle Aged
dc.subjectNeoplasm Grading
dc.subjectNevus, Pigmented
dc.subjectRetrospective Studies
dc.subjectSkin Neoplasms
dc.subjectYoung Adult
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectdermatologist
dc.subjectdermatoscopy
dc.subjectdysplasia
dc.subjectfemale
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmelanocytic lesion with peripheral globule
dc.subjectmelanoma
dc.subjectphenotype
dc.subjectpigmented nevus
dc.subjectPolarized light dermoscopy
dc.subjectretrospective study
dc.subjectadolescent
dc.subjectage
dc.subjectcancer grading
dc.subjectdermatoscopy
dc.subjectdysplastic nevus syndrome
dc.subjectmelanoma
dc.subjectmiddle aged
dc.subjectpathology
dc.subjectskin tumor
dc.subjectsurgery
dc.subjectyoung adult
dc.titleCan we manage the melanocytic lesions with peripheral globules according to the grade of dysplasia?
dc.typeArticle

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