Predicting factors of acute kidney injury after partial nephrectomy and its impact on long-term renal function: A multicentre study of the Turkish Urooncology Association

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dc.contributor.authorSuer E.
dc.contributor.authorAkpinar C.
dc.contributor.authorIzol V.
dc.contributor.authorBayazit Y.
dc.contributor.authorSozen S.
dc.contributor.authorCetin S.
dc.contributor.authorOzden E.
dc.contributor.authorTurkeri L.
dc.contributor.authorBozkurt O.
dc.contributor.authorUcer O.
dc.contributor.authorBaltaci S.
dc.date.accessioned2024-07-22T08:05:28Z
dc.date.available2024-07-22T08:05:28Z
dc.date.issued2021
dc.description.abstractObjectives: To investigate the predictors of acute kidney injury (AKI) after partial nephrectomy and the impact of AKI stage on long-term kidney function. Methods: Data of 1055 patients who underwent partial nephrectomy between January 2008 and January 2018 at seven separate tertiary centres were analysed. AKI was defined according to AKI Network criteria. The association between pre-operative and perioperative factors and AKI was evaluated using logistic regression analysis. Recovery of at least 90% of baseline glomerular filtration rate 1 year after partial nephrectomy, change of 1 year glomerular filtration rate compared with baseline glomerular filtration rate and stage ≥3 chronic kidney disease (CKD) progression were assessed according to the stage of AKI. Results: AKI was recorded in 281 (26.7%) of 1055 patients after partial nephrectomy, and of these patients, 197 (70.1%) had stage 1, 77 (27.4%) had stage 2 and 7 (2.5%) had stage 3. Higher tumour complexity and baseline glomerular filtration rate were independent predictors for AKI. The proportion of recovering 90% of baseline glomerular filtration rate at 1 year for any patient who had stage ≤1 vs stage 2-3 of AKI was 78.2% (95% CI: 73.2%-83.7%) and 23.8% (95% CI: 14.7%-38.7%), respectively (P <.001). The risk of stage ≥3 CKD progression for any patient who had stage ≤1 vs stage 2-3 of AKI was 6.2% (95% CI: 4.1%-9.2%) and 63.1% (95% CI: 52.5%-75.6%), respectively (P <.001). Conclusions: AKI adversely affects renal function in the long-term after partial nephrectomy and stage 2-3 significantly increases the risk of CKD in the long term. © 2021 John Wiley & Sons Ltd.
dc.identifier.DOI-ID10.1111/ijcp.14751
dc.identifier.issn13685031
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13154
dc.language.isoEnglish
dc.publisherJohn Wiley and Sons Inc
dc.rightsAll Open Access; Gold Open Access
dc.subjectAcute Kidney Injury
dc.subjectGlomerular Filtration Rate
dc.subjectHumans
dc.subjectKidney
dc.subjectKidney Neoplasms
dc.subjectNephrectomy
dc.subjectRenal Insufficiency, Chronic
dc.subjectRetrospective Studies
dc.subjectRisk Factors
dc.subjectTreatment Outcome
dc.subjectacute kidney failure
dc.subjectArticle
dc.subjectchronic kidney failure
dc.subjectdisease course
dc.subjectfemale
dc.subjectglomerulus filtration rate
dc.subjecthealth care organization
dc.subjecthuman
dc.subjectkidney function
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpartial nephrectomy
dc.subjectpostoperative complication
dc.subjectretrospective study
dc.subjectacute kidney failure
dc.subjectadverse event
dc.subjectchronic kidney failure
dc.subjectclinical trial
dc.subjectkidney
dc.subjectkidney tumor
dc.subjectmulticenter study
dc.subjectnephrectomy
dc.subjectphysiology
dc.subjectrisk factor
dc.subjecttreatment outcome
dc.titlePredicting factors of acute kidney injury after partial nephrectomy and its impact on long-term renal function: A multicentre study of the Turkish Urooncology Association
dc.typeArticle

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