Histopathological effects of sildenafil citrate on rat corpus cavernosum

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dc.contributor.authorGümüs B.
dc.contributor.authorVatansever H.S.
dc.contributor.authorMüezzinoǧlu T.
dc.contributor.authorMüftüoǧluc S.
dc.contributor.authorKaymaz F.
dc.contributor.authorBüyüksu C.
dc.date.accessioned2024-07-22T08:24:36Z
dc.date.available2024-07-22T08:24:36Z
dc.date.issued2004
dc.description.abstractSildenafil citrate (Viagra) is widely used for the treatment of erectile dysfunction with various etiologies. The aim of the present study was the investigation of histopathological effects of sildenafil citrate on rat corpus cavernosum using light and electron microscopical techniques. Twenty male rats were divided into two groups. The first group (n = 10) was used as a control and the second group (n = 10) was treated with sildenafil citrate. Penile tissue was collected, fixed with formalin and embedded in paraffin for light microscopy, or fixed with gluteraldehyde and osmium tetroxide and embedded in Epon for electron microscopy. Light microscopical analysis showed that the corpus cavernosum was elongated and the number of blood vessels was increased. The amount of connective tissue in the penis was increased and dense collagen and smooth muscle fibers were observed in treated rats. Electron microscopical analysis showed that stromal structures of the corpus cavernosum (collagen fibers and number of cellular elements) were increased in treated rats. Fibroblasts showed signs of activation and the number of other stromaL cells was increased. Immature newly synthesized collagen fibers were observed and penetrated endothelial basement membranes. In addition, endothelial cells also showed signs of activation such as cytoplasmic granules in treated rats, whereas the surface area of blood vessels was increased and basement membranes were thickened. These histopathological changes due to treatment with sildenafil citrate indicate that prolonged use of sildenafil citrate may increase the risk of fibrosis in the penis. © 2003 Elsevier GmbH. All rights reserved.
dc.identifier.DOI-ID10.1016/j.acthis.2003.11.002
dc.identifier.issn00651281
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20048
dc.language.isoEnglish
dc.publisherElsevier GmbH
dc.subjectBlood
dc.subjectCollagen
dc.subjectElectron microscopy
dc.subjectHistology
dc.subjectOptical microscopy
dc.subjectOsmium compounds
dc.subjectPathology
dc.subjectTissue
dc.subjectcollagen fiber
dc.subjectglutaraldehyde
dc.subjectosmium tetraoxide
dc.subjectsildenafil
dc.subjectEndothelial cells
dc.subjectHistopathological effects
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectbasement membrane
dc.subjectblood vessel
dc.subjectcell activation
dc.subjectcell granule
dc.subjectcollagen synthesis
dc.subjectconnective tissue
dc.subjectcontrolled study
dc.subjectcorpus cavernosum
dc.subjectdrug effect
dc.subjectelectron microscopy
dc.subjectendothelium cell
dc.subjecterectile dysfunction
dc.subjecthistopathology
dc.subjectmale
dc.subjectnonhuman
dc.subjectpenile fibrosis
dc.subjectrat
dc.subjectrisk assessment
dc.subjectsmooth muscle fiber
dc.subjectBiomedical engineering
dc.titleHistopathological effects of sildenafil citrate on rat corpus cavernosum
dc.typeArticle

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