Evaluation of VEGF in placental bed biopsies from preeclamptic women by immunohistochemistry
| dc.contributor.author | Cirpan, T | |
| dc.contributor.author | Akercan, F | |
| dc.contributor.author | Terek, MC | |
| dc.contributor.author | Kazandi, M | |
| dc.contributor.author | Ozcakir, HT | |
| dc.contributor.author | Giray, G | |
| dc.contributor.author | Sagol, S | |
| dc.date.accessioned | 2025-04-10T10:33:12Z | |
| dc.date.available | 2025-04-10T10:33:12Z | |
| dc.description.abstract | Objective: The aim of the study was to determine VEGF protein with immunohistochemical staining in placental bed biopsies of preeclamptic pregnancies in comparison to normal controls. Design: Prospective cohort Study. Methods: The placental bed biopsies were obtained from 12 patients with preeclapmsia and ten patients for a control group at the time of cesarean delivery. Tissue samples of the placental bed were examined for VEGF protein distribution with avidin-biotin-peroxidase immunohistochemistry. Two blinded histopathologists were asked to score each sample for the intensity of staining and the number of cells stained in a randomly selected HPF of each sample. The resulting H-score was computed as a product of intensity and percent of cells stained. Results: VEGF expression was significantly lower in both the myometrium and stroma of the preeclamptic group compared to the control group (77.2 +/- 25.4 vs 134 +/- 44.3, p = 0.007; 194.1 +/- 20.7 vs 170.2 +/- 17, p = 0.017, respectively). Conclusion: VEGF expression is significantly lower in placental bed biopsies of preeclamptic pregnancies. | |
| dc.identifier.issn | 0390-6663 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/39510 | |
| dc.language.iso | English | |
| dc.title | Evaluation of VEGF in placental bed biopsies from preeclamptic women by immunohistochemistry | |
| dc.type | Article |