Is the menstrual cycle affecting the skin prick test reactivity?

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dc.contributor.authorKirmaz C.
dc.contributor.authorYuksel H.
dc.contributor.authorMete N.
dc.contributor.authorBayrak P.
dc.contributor.authorBaytur Y.B.
dc.date.accessioned2024-07-22T08:24:24Z
dc.date.available2024-07-22T08:24:24Z
dc.date.issued2004
dc.description.abstractAllergen skin prick tests (SPT) are very sensitive and specific tests to detect allergic sensitization in atopic patients. Certain factors like antihistamines, antidepressant therapies or circadian rhythms can alter the results of SPT. In women, the changes in endogenous hormone levels throughout the menstrual cycle may affect the allergic responses and natural course of allergic diseases. The aim of this study was to investigate the probable influence of the phases of the menstrual cycle on SPT reactivity to allergen extracts and histamine. Forty-two female patients with seasonal allergic rhinoconjunctivitis were enrolled in the study. Skin prick test reactivities to allergens and histamine were measured at the beginning of the menstrual cycle (3rd or 4th day), mid-cycle (14th or 15th day) and end-cycle (27th or 28th day) consecutively. Serum estradiol, progesterone, luteinizing hormone (LH), and follicle stimulating hormone (FSH) levels were determined simultaneously. We observed the most significant reactions to allergens when SPT is performed at mid-cycle. However, SPT reactivity to histamine did not vary throughout the menstrual cycle. Serum estradiol and LH levels showed positive correlation with SPT reactivity to allergens at mid-cycle. Our results suggest that SPT give the best results when they are performed at mid-cycle. Additionally, allergens seem to cause mast cell degranulation to a greater extent in subjects in which endogenous hormones like estradiol and LH are elevated.
dc.identifier.issn0125877X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19966
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAllergens
dc.subjectConjunctivitis, Allergic
dc.subjectEstradiol
dc.subjectFemale
dc.subjectFollicle Stimulating Hormone
dc.subjectHistamine
dc.subjectHumans
dc.subjectHypersensitivity
dc.subjectLuteinizing Hormone
dc.subjectMenstrual Cycle
dc.subjectProgesterone
dc.subjectRhinitis, Allergic, Seasonal
dc.subjectSkin Tests
dc.subjectTime Factors
dc.subjectallergen
dc.subjectestradiol
dc.subjectfollitropin
dc.subjecthistamine
dc.subjectluteinizing hormone
dc.subjectprogesterone
dc.subjectadult
dc.subjectarticle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcorrelation function
dc.subjectestradiol blood level
dc.subjectfemale
dc.subjectfollitropin blood level
dc.subjecthay fever
dc.subjecthuman
dc.subjectimmunoreactivity
dc.subjectluteinizing hormone blood level
dc.subjectmast cell degranulation
dc.subjectmenstrual cycle
dc.subjectprick test
dc.subjectprogesterone blood level
dc.titleIs the menstrual cycle affecting the skin prick test reactivity?
dc.typeArticle

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