The correlation between unexplained infertility and exosomes

Simple item page
dc.contributor.authorUyar Y.
dc.contributor.authorÖzgül M.
dc.contributor.authorGökalp S.
dc.contributor.authorOk G.
dc.contributor.authorTan A.
dc.contributor.authorVatansever H.S.
dc.date.accessioned2024-07-22T08:08:04Z
dc.date.available2024-07-22T08:08:04Z
dc.date.issued2020
dc.description.abstractObjectives: Endometrial receptivity plays the most important role for successful implantation. Increasing endometrial receptivity may improve infertility and increase Assisted Reproductive Technologies success. The aim of this study was to investigate the effect of exosome specific markers CD63 and CD9 which are promising molecules in the pathogenesis and treatment of many diseases on endometrial receptivity in women with unexplained infertility. Material and methods: This prospective study was conducted between November 2015 and March 2017. Proliferation and secretion periods of endometrial samples from fertile and infertile cases were collected. The paraffin-embedded tissue sections were stained with hematoxylin-eosin for the immunohistochemical analysis distributions of CD63 and CD9. Results: The results of this study demonstrated that the CD63 immunoreactivity was higher in both luminal and glandular epithelium of infertile patients when compared with fertile patients during the proliferative phase (p = 0.009, p = 0.008). In the infertile proliferation phase, endometrium CD9 immunoreactivity was rarely detected in both the luminal and glandular epithelium. In the secretion phase of endometrium, CD9 immunoreactivity was mild in fertile patients, the increased immunoreactivity of CD9 was observed in both luminal and glandular epithelium of infertile patients (p = 0.037, p = 0.037). Conclusions: Increased levels of CD63 in infertile proliferation phase endometrium should represent an unfavorable signaling. Moreover, the increased levels of CD9 in infertile secretion phase endometrium could be used as a biomarker to evaluate endometrial receptivity. These exosome-specific markers can be considered as potential molecular markers of infertility. © 2020, Via Medica.
dc.identifier.DOI-ID10.5603/GP.2020.0048
dc.identifier.issn00170011
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14248
dc.language.isoEnglish
dc.publisherVia Medica
dc.rightsAll Open Access; Gold Open Access
dc.subjectAdult
dc.subjectEndometrium
dc.subjectExosomes
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectInfertility, Female
dc.subjectMenstrual Cycle
dc.subjectProspective Studies
dc.subjectTetraspanin 29
dc.subjectTetraspanin 30
dc.subjectCD63 antigen
dc.subjectCD63 protein, human
dc.subjectCD9 antigen
dc.subjectCD9 protein, human
dc.subjectadult
dc.subjectendometrium
dc.subjectexosome
dc.subjectfemale
dc.subjectfemale infertility
dc.subjecthuman
dc.subjectimmunohistochemistry
dc.subjectmenstrual cycle
dc.subjectmetabolism
dc.subjectpathology
dc.subjectphysiology
dc.subjectprospective study
dc.titleThe correlation between unexplained infertility and exosomes
dc.typeArticle

Files

Collections

Scopus Koleksiyonu