Muscle-specific PPARβ/δ agonism may provide synergistic benefits with life style modifications

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dc.contributor.authorErol A.
dc.date.accessioned2024-07-22T08:22:29Z
dc.date.available2024-07-22T08:22:29Z
dc.date.issued2007
dc.description.abstractPeroxisome proliferator-activated receptor β/δ (PPARβ/δ) has emerged as a powerful metabolic regulator in diverse tissues including fat, skeletal muscle, and the heart. It is now established that activation of PPARβ/δ promotes fatty acid oxidation in several tissues, such as skeletal muscle and adipose tissue. In muscle, PPARβ/δ appears to act as a central regulator of fatty acid catabolism. PPARβ/δ contents are increased in muscle during physiological situations such as physical exercise or long-term fasting, characterized by increased fatty acid oxidation. Targeted expression of an activated form of PPARβ/δ in skeletal muscle induces a switch to form increased numbers of type I muscle fibers resembling the fiber type transition by endurance training. Activation of PPARβ/δ also enhances mitochondrial capacity and fat oxidation in the skeletal muscle that resembles the effect of regular exercise. Therefore, it is hypothesized that muscle-specific PPARβ/δ agonists could be a key strategy to support the poor cardiorespiratory fitness associated with metabolic disorders. Copyright © 2007 Adnan Erol.
dc.identifier.DOI-ID10.1155/2007/30578
dc.identifier.issn16874765
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19076
dc.language.isoEnglish
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectlipid
dc.subjectperoxisome proliferator activated receptor delta agonist
dc.subjectcell proliferation
dc.subjectcolon carcinogenesis
dc.subjectfitness
dc.subjectgenetic transcription
dc.subjectheart muscle cell
dc.subjecthormone action
dc.subjecthuman
dc.subjecthypothesis
dc.subjectinsulin resistance
dc.subjectlifestyle modification
dc.subjectmetabolic disorder
dc.subjectmetabolic syndrome X
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectnonhuman
dc.subjectobesity
dc.subjectreview
dc.subjectrisk benefit analysis
dc.subjectweight gain
dc.titleMuscle-specific PPARβ/δ agonism may provide synergistic benefits with life style modifications
dc.typeReview

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