Clinical performance of ASAS Health Index in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: real-world evidence from Multicenter Nationwide Registry
No Thumbnail Available
Date
2020
Journal Title
Journal ISSN
Volume Title
Abstract
The Assessment of SpondyloArthritis international Society Health Index (ASAS HI) is used as a new instrument in measuring the function, disability and health of patients with spondyloarthritis (SpA). However, the real-world evidence of ASAS HI is very limited. In the present study, our objective is to evaluate the psychometric properties and performance of ASAS HI in the real-world setting as well as comparing ASAS HI with the current instruments to assess the construct validity and determine the cut-off points in patients with both ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). A total of 991 patients with axSpA who fulfilled either the ASAS classification criteria for axial SpA (axSpA) or the Modified New York Criteria (mNY) for AS were recruited from the Biologic and targeted Synthetic antirheumatic drugs Registry (BioStaR) SpA. The construct validity of ASAS HI against the Bath Ankylosing Spondylitis Disease Activities Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score–C-Reactive Protein (ASDAS-CRP) the Bath Ankylosing Spondylitis Functional index (BASFI) was performed. Using the receiver operating characteristic (ROC) curves analysis, the cut-off points were calculated. Of all the recruited patients, 851 (85.9%) were AS and 140 (14.1%) were nr-axSpA. The difference in the mean ASAS HI scores of the patients with AS and the ones with nr-axSpA were not statistically significant (6.12 ± 4.29 and 6.42 ± 4.86, respectively). The mean ASAS HI score was significantly higher in females and small city residents. The ASAS HI had a strong construct validity against ASDAS-CRP, BASDAI and BASFI. A cut-off point of ≤ 4 was determined to discriminate good and moderate, as well as ≥ 12 to discriminate moderate and poor health status. In conclusion, ASAS HI is a reliable instrument to evaluate health and functioning for both patients with AS and nr-axSpA in clinical practice. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Description
Keywords
Activities of Daily Living , Adult , Female , Humans , Male , Middle Aged , Psychometrics , Quality of Life , Registries , Reproducibility of Results , Spondylarthropathies , Spondylitis, Ankylosing , Surveys and Questionnaires , Turkey , adult , ankylosing spondylitis , Ankylosing Spondylitis Disease Activity Score , Ankylosing Spondylitis Disease Activity Score C Reactive Protein , Article , assessment of spondyloarthritis international society classification , Assessment of SpondyloArthritis international Society Health Index , Bath ankylosing spondylitis disease activity index , Bath ankylosing spondylitis functional index , clinical evaluation , cohort analysis , construct validity , cross-sectional study , discriminant validity , disease activity , disease classification , disease registry , female , functional status , health status , human , intermethod comparison , major clinical study , male , Modified New York Criteria , musculoskeletal disease assessment , observational study , priority journal , psychometry , quality of life , quality of life assessment , reference value , reliability , sensitivity and specificity , sex difference , spondylarthritis , urban population , ankylosing spondylitis , clinical trial , daily life activity , diagnostic imaging , middle aged , multicenter study , pathophysiology , questionnaire , register , reproducibility , spondyloarthropathy , turkey (bird)