Etiologic risk factors and vitamin D receptor gene polymorphisms in under one-year-old infants with urolithiasis

Simple item page
dc.contributor.authorErgon E.Y.
dc.contributor.authorAkil İ.O.
dc.contributor.authorTaneli F.
dc.contributor.authorOran A.
dc.contributor.authorOzyurt B.C.
dc.date.accessioned2024-07-22T08:09:38Z
dc.date.available2024-07-22T08:09:38Z
dc.date.issued2018
dc.description.abstractThe incidence of urinary tract stones in infancy has been increasing in Turkey. Risk factors and vitamin D receptor (VDR) gene polymorphisms were investigated in infants aged < 1 year who had stones. Forty infants with urinary tract stones and 80 infants without stones, aged < 1 year were enrolled in this study. Detailed surveys were taken of all infants, metabolic parameters and ApaI and FokI VDR gene polymorphisms were investigated. Infants with stones tended to be more commonly fed formula and multivitamins (vitamins A, C, D) (p < 0.05). Positive family history came into prominence in the stony group (p < 0.05). There were no significant differences in ApaI and FokI VDR gene polymorphisms between the groups with stones and the control groups. However, CA genotype of ApaI polymorphism was associated with family history and C allele of ApaI was related with family history and hypercalciuria (p < 0.05). Hypercalciuria emerged as an underlying metabolic abnormality in the etiology of stones, and was observed at a rate of 38%. Infants who are given formula and multivitamins for vitamin D supplementation are at increased risk for the formation of urinary tract stones. VDR gene polymorphisms cause the formation of urinary tract stones and affect calcium (Ca) metabolism. © 2017, Springer-Verlag GmbH Germany.
dc.identifier.DOI-ID10.1007/s00240-017-1009-7
dc.identifier.issn21947228
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14882
dc.language.isoEnglish
dc.publisherSpringer Verlag
dc.subjectCalcium
dc.subjectCase-Control Studies
dc.subjectDiet Surveys
dc.subjectDietary Supplements
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenetic Predisposition to Disease
dc.subjectHumans
dc.subjectHypercalciuria
dc.subjectIncidence
dc.subjectInfant
dc.subjectInfant Formula
dc.subjectInfant, Newborn
dc.subjectMale
dc.subjectPolymorphism, Restriction Fragment Length
dc.subjectReceptors, Calcitriol
dc.subjectRisk Factors
dc.subjectTurkey
dc.subjectUrolithiasis
dc.subjectVitamin D
dc.subjectcalcium
dc.subjectmultivitamin
dc.subjectvitamin D
dc.subjectvitamin D receptor
dc.subjectcalcitriol receptor
dc.subjectcalcium
dc.subjectVDR protein, human
dc.subjectvitamin D
dc.subjectallele
dc.subjectArticle
dc.subjectartificial milk
dc.subjectcalcium metabolism
dc.subjectcalcium urine level
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectDNA polymorphism
dc.subjectfamily history
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgenetic risk
dc.subjectgenotype
dc.subjecthuman
dc.subjecthypercalciuria
dc.subjectinfant
dc.subjectmale
dc.subjectmetabolic parameters
dc.subjectpriority journal
dc.subjectrisk assessment
dc.subjecturolithiasis
dc.subjectvitamin supplementation
dc.subjectcase control study
dc.subjectdiet
dc.subjectdietary supplement
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjecthypercalciuria
dc.subjectincidence
dc.subjectmetabolism
dc.subjectnewborn
dc.subjectrandomized controlled trial
dc.subjectrestriction fragment length polymorphism
dc.subjectrisk factor
dc.subjectturkey (bird)
dc.subjecturine
dc.subjecturolithiasis
dc.titleEtiologic risk factors and vitamin D receptor gene polymorphisms in under one-year-old infants with urolithiasis
dc.typeArticle

Files

Collections

Scopus Koleksiyonu