Neuroprotective effects of oleocanthal, a compound in virgin olive oil, in a rat model of traumatic brain injury

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dc.contributor.authorMete M.
dc.contributor.authorAydemir I.
dc.contributor.authorUnsal U.U.
dc.contributor.authorCollu F.
dc.contributor.authorVatandas G.
dc.contributor.authorGurcu B.
dc.contributor.authorDuransoy Y.K.
dc.contributor.authorTaneli F.
dc.contributor.authorTuglu M.I.
dc.contributor.authorSelcuki M.
dc.date.accessioned2024-07-22T08:10:13Z
dc.date.available2024-07-22T08:10:13Z
dc.date.issued2018
dc.description.abstractAIM: To evaluate the neuroprotective effects of deocanthal OC in a rat model of traumatic brain injury (TBI). MATERIAL and METHODS: Twenty-six adult male, Wistar albino rats were used. The rats were divided into 4 groups. Group 1 was the sham group (n = 5). Group 2 was the trauma group (n = 5) where rats were treated with 10 mg/kg saline intraperitoneally (IP) twice a day. Groups 3 and 4, rats were treated with 10 (group 3, n = 8) or 30 (group 4, n = 8) mg/kg OC IP twice a day. For each group, brain samples were collected 72 hours after injury. Brain samples and blood were evaluated with histopathological and biochemical methods. RESULTS: Histopathological evaluation revealed a significant difference between Group 2 and Group 4. Biochemical findings demonstrated that the oxidative stress index was highest in Group 2 and lowest in Group 4. CONCLUSION: OC has a protective effect on neural cells after TBI. This effect is achieved by reducing oxidative stress and apoptosis. © 2018 Turkish Neurosurgical Society.
dc.identifier.DOI-ID10.5137/1019-5149.JTN.21417-17.2
dc.identifier.issn10195149
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15138
dc.language.isoEnglish
dc.publisherTurkish Neurosurgical Society
dc.rightsAll Open Access; Bronze Open Access; Green Open Access
dc.subjectAldehydes
dc.subjectAnimals
dc.subjectApoptosis
dc.subjectBrain
dc.subjectBrain Injuries, Traumatic
dc.subjectDisease Models, Animal
dc.subjectMale
dc.subjectNeuroprotective Agents
dc.subjectOlive Oil
dc.subjectOxidative Stress
dc.subjectPhenols
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectaldehyde
dc.subjectneuroprotective agent
dc.subjectoleocanthal
dc.subjectolive oil
dc.subjectphenol derivative
dc.subjectanimal
dc.subjectapoptosis
dc.subjectbrain
dc.subjectchemistry
dc.subjectdisease model
dc.subjectdrug effect
dc.subjectmale
dc.subjectoxidative stress
dc.subjectpathology
dc.subjectrat
dc.subjecttraumatic brain injury
dc.subjectWistar rat
dc.titleNeuroprotective effects of oleocanthal, a compound in virgin olive oil, in a rat model of traumatic brain injury
dc.typeArticle

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