Treatment of intrathecal methotrexate overdose with folinic acid rescue and lumbar cerebrospinal fluid exchange: A report of two cases; [Yüksek doz intratekal metotreksat'ın folinik asit ve beyin omurilik sıvısı deg̈işimi ile tedavisi: Ïki olgu sunumu]

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dc.contributor.authorKazanci E.
dc.contributor.authorGülen H.
dc.contributor.authorErbay A.
dc.contributor.authorVergin C.
dc.date.accessioned2024-07-22T08:20:38Z
dc.date.available2024-07-22T08:20:38Z
dc.date.issued2011
dc.description.abstractWe report two male cases (4- and 5-years-old) of intrathecal methotrexate overdose. The two boys with acute lymphoblastic leukemia were to receive intrathecal injection of methotrexate. Instead of the prescribed 12 mg, they both received a dose of 120 mg. The initial cerebrospinal fluid samples showed methotrexate concentration of 2.24×10-2M in case 1 and 1.32×10-2M in case 2. The cases were successfully treated with cerebrospinal fluid (CSF) exchange and intravenous folinic acid rescue. The favorable outcome in our cases suggests that CSF exchange is safe and that folinic acid rescue may be adequate to prevent sequelae in patients subjected to intrathecal MTX overdoses up to 120 mg. We propose CSF exchange and intravenous folinic acid as the mainstay of treatment. In addition to the staff 's failure to check the drug label carefully, the marked resemblance of the two dose preparations of MTX may have been contributory.
dc.identifier.DOI-ID10.5152/tjh.2011.08
dc.identifier.issn13007777
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18257
dc.language.isoTurkish
dc.publisherTurkish Society of Hematology
dc.rightsAll Open Access; Gold Open Access
dc.subjectfolinic acid
dc.subjectmethotrexate
dc.subjectacute lymphoblastic leukemia
dc.subjectarticle
dc.subjectcase report
dc.subjectcerebrospinal fluid analysis
dc.subjectchild
dc.subjectdrug cerebrospinal fluid level
dc.subjectdrug overdose
dc.subjecthuman
dc.subjectlumbar spine
dc.subjectmale
dc.subjectpreschool child
dc.subjectsafety
dc.subjecttreatment outcome
dc.titleTreatment of intrathecal methotrexate overdose with folinic acid rescue and lumbar cerebrospinal fluid exchange: A report of two cases; [Yüksek doz intratekal metotreksat'ın folinik asit ve beyin omurilik sıvısı deg̈işimi ile tedavisi: Ïki olgu sunumu]
dc.typeArticle

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