Giardiasis treatment in Turkish children with a single dose of ornidazole

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dc.contributor.authorÖzbilgin A.
dc.contributor.authorErtan P.
dc.contributor.authorYereli K.
dc.contributor.authorTamay A.T.
dc.contributor.authorKurt Ö.
dc.contributor.authorDegerli K.
dc.contributor.authorBalcioglu I.C.
dc.contributor.authorOk Ü.Z.
dc.contributor.authorOnag A.
dc.date.accessioned2024-07-22T08:25:17Z
dc.date.available2024-07-22T08:25:17Z
dc.date.issued2002
dc.description.abstractThis study was designed to compare the treatment efficacy of single dose of ornidazole with 5 d treatments of ornidazole and metronidazole in children with giardiasis. 175 children, between 2 and 15 y old, whose stool samples were found to be positive for Giardia lamblia cysts and/or trophozoites by either saline-Lugol, formalin-ethyl acetate or trichrome staining, were enrolled in the study. Of these children, 105 were treated with a single dose of ornidazole: 35 with 30 mg/kg, 35 with 25 mg/kg and 35 with 20 mg/kg; 35 were treated with 25 mg/kg per day of ornidazole for 5 d in 2 doses and 35 children were treated with 20 mg/kg per day metronidazole for 7 d in 3 doses. All cases were examined on the 7th, 10th and 14th days after treatment by the same methods; clinical symptoms were also evaluated. Giardia lamblia was eradicated in 34 of 35 (97%), 34 of 35 (97%) and 33 of 35 (94%) patients treated with 30, 25 and 20 mg/kg single doses of ornidazole, respectively. Eradication was achieved in all 35 patients treated with 25 mg/kg per day ornidazole for 5 d and in 31 of 35 (89%) patients treated with metronidazole. There was no statistically significant difference among doses of ornidazole (p > 0.05); however, all ornidazole treatment regimens were significantly more effective than metronidazole treatment (p < 0.05). No important side-effects were detected in any patients and clinical symptoms disappeared in all. Single-dose ornidazole treatment could be considered as a proper and effective alternative method for the treatment of giardiasis in children.
dc.identifier.DOI-ID10.1080/0036554021000026962
dc.identifier.issn00365548
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20354
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAntiprotozoal Agents
dc.subjectChild, Preschool
dc.subjectGiardiasis
dc.subjectHumans
dc.subjectMetronidazole
dc.subjectOrnidazole
dc.subjectTreatment Outcome
dc.subjectTurkey
dc.subjectacetic acid ethyl ester
dc.subjectbiteral
dc.subjectformaldehyde
dc.subjectlugol
dc.subjectmetronidazole
dc.subjectornidazole
dc.subjectsecnidazole
dc.subjectsodium chloride
dc.subjecttinidazole
dc.subjectadolescent
dc.subjectarticle
dc.subjectchild
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectdrug elimination
dc.subjecteradication therapy
dc.subjectfeces analysis
dc.subjectfemale
dc.subjectGiardia lamblia
dc.subjectgiardiasis
dc.subjectheadache
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnausea
dc.subjectside effect
dc.subjectstaining
dc.subjectstatistical analysis
dc.subjectstatistical significance
dc.subjecttaste disorder
dc.subjecttreatment outcome
dc.subjecttrophozoite
dc.subjectTurkey (republic)
dc.subjectxerostomia
dc.titleGiardiasis treatment in Turkish children with a single dose of ornidazole
dc.typeArticle

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