Preparation and in vitro characterization of electrospun 45S5 bioactive glass nanofibers

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dc.contributor.authorDeliormanli A.M.
dc.date.accessioned2024-07-22T08:14:35Z
dc.date.available2024-07-22T08:14:35Z
dc.date.issued2015
dc.description.abstractBioactive glasses are widely used in biomedical applications due to their ability to bond to bone and even to soft tissues. In this study, 45S5 bioactive glass fibers were prepared through sol-gel processing and electrospinning technique. A precursor solution containing poly vinyl alcohol and bioactive glass sol was used to produce fibers. The mixture was electrospun at a voltage of 20 kV by maintaining tip to a collector distance of 8 cm. The fibers with an average diameter of 337781 nm (before calcination) were successfully obtained. Results showed that the crystalline phase of the fibers was largely influenced by the calcination temperature. Hydroxyapatite formation on calcined 45S5 fibers was investigated in simulated body fluid (SBF) using different fiber/SBF (F/S) ratios (0.5, 1, 2 and 10 mg/ml) at 37 °C. When immersed in SBF, conversion to a calcium phosphate material showed a strong dependence on the F/S ratio. At high solid concentration (10 mg/ml), surface of the fibers could not be converted to the HA-like material in SBF after 30 days. At lower solid concentrations (2, 1 and 0.5 mg/ml) an amorphous calcium phosphate layer formation was observed followed by the conversion to hydroxyapatite. © 2014 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
dc.identifier.DOI-ID10.1016/j.ceramint.2014.08.086
dc.identifier.issn02728842
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16617
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.subjectBioactive glass
dc.subjectBody fluids
dc.subjectCalcination
dc.subjectCalcium phosphate
dc.subjectFibers
dc.subjectHydroxyapatite
dc.subjectMedical applications
dc.subjectNanocrystalline materials
dc.subjectSol-gel process
dc.subjectTissue
dc.subjectTissue engineering
dc.subjectAmorphous calcium phosphate
dc.subjectBiomedical applications
dc.subjectCalcination temperature
dc.subjectCalcium phosphate materials
dc.subjectElectrospinning techniques
dc.subjectHigh solid concentration
dc.subjectHydroxyapatite formations
dc.subjectTissue engineering applications
dc.subjectElectrospinning
dc.titlePreparation and in vitro characterization of electrospun 45S5 bioactive glass nanofibers
dc.typeArticle

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