Chronic inflammation: A poor prognostic factor for endoscopic dacryocystorhinostomy

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dc.contributor.authorÖzer Ö.
dc.contributor.authorEskiizmir G.
dc.contributor.authorÜnlü H.
dc.contributor.authorIşisaǧ A.
dc.contributor.authorAsian A.
dc.date.accessioned2024-07-22T08:19:29Z
dc.date.available2024-07-22T08:19:29Z
dc.date.issued2012
dc.description.abstractEndoscopic endonasal dacryocystorhinostomy (En-DCR) success can be affected by many factors. In this study, we aimed to determine the effect of chronic inflammation on the surgical outcome of En-DCR. A series of 25 primary En-DCR cases and their lacrimal sac specimens were involved in the study. The surgical outcomes were assessed subjectively (satisfied and unsatisfied) and objectively (successful and unsuccessful). All the specimens were examined for the chronic inflammation related histopathological features (inflammatory cell infiltration, fibrosis and capillary proliferation) and graded according to their severity. Moreover, a "chronic inflammation score" was established to determine the intensity of chronic inflammation using the grade of histopathological features. A quantitative and statistical analysis of histopathological features and chronic inflammation were performed between patients with satisfactory and unsatisfactory outcome; and patients with successful and unsuccessful outcome. The overall success rate according to subjective and objective assessment was 60%. However, 9 of 10 patients with unsatisfactory and/or unsuccessful outcome (90%) had severe chronic inflammation of lacrimal sac. In subjective assessment, inflammatory cell infiltration (p = 0.050), fibrosis (p = 0.037), capillary proliferation (p = 0.007) and chronic inflammation (p = 0.003) had a statistically significant difference between patients with satisfactory and unsatisfactory outcome. In objective assessment, statistically significant differences were detected between patients with successful and unsuccessful outcome when they compared according to inflammatory cell infiltration (p = 0.027), capillary proliferation (p = 0.007) and chronic inflammation (p = 0.003). Chronic inflammation related histopathological features of variable degree may have a role on En-DCR outcome. Chronic inflammatory score can be used as an indicator of En-DCR success. © 2011 Springer-Verlag.
dc.identifier.DOI-ID10.1007/s00405-011-1728-2
dc.identifier.issn14344726
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17696
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAged
dc.subjectDacryocystorhinostomy
dc.subjectEndoscopy
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectInflammation
dc.subjectLacrimal Duct Obstruction
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNasolacrimal Duct
dc.subjectPrognosis
dc.subjectTreatment Outcome
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectcapillary proliferation
dc.subjectcell infiltration
dc.subjectchronic inflammation
dc.subjectclinical article
dc.subjectdacryocystorhinostomy
dc.subjectdisease severity
dc.subjectendoscopic surgery
dc.subjectfemale
dc.subjectfibrosis
dc.subjecthistopathology
dc.subjecthuman
dc.subjectlacrimal sac
dc.subjectmale
dc.subjectoutcome assessment
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectsurgical technique
dc.titleChronic inflammation: A poor prognostic factor for endoscopic dacryocystorhinostomy
dc.typeArticle

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